TY - JOUR AB - Suppurative hidradenitis and pyoderma gangrenosum are rare disorders that can be seen isolated or even more rare, as part of different autoinflammatory syndromes: Pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH), pyoderma gangrenosum, acne, pyogenic arthritis, and hidradenitis suppurativa (PAPASH) or psoriatic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PsAPASH). Although they have different clinical features, suppurative hidradenitis and pyoderma gangrenosum seem to share similar pathogenic pathways involving a dysregulated innate immune system, with neutrophilic inflammation, mediated by IL‑1β, controlled by NALP3 inflammasome pathway. We report a case of a 53‑year‑old male patient previously diagnosed with HS in inguinal‑scrotal area that developed rapidly after a traumatic injury on his left anterior calf, a painful inflammatory plaque with pustules on the surface that rapidly progressed (24‑48 h) to form ulcers. The lesions ended up healing with a large scarring plaque with cribriform openings, multiple fibrous bridges, open comedones, and double‑ended pseudo‑comedones. Although the clinical aspect at presentation together with the aspect on the first biopsy were suggestive for pyoderma gangrenosum, the healing aspect is more commonly seen in suppurative hidradenitis. Commonly seen in acne, in the healing phase of suppurative hidradenitis but more rarely in pyoderma gangrenosum, the formation of comedones seem to be a complex process and raise the question if these entities represent in our patient an association, an overlap or the spectrum of the same disease. AD - Department of Dermatology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania Department of Dermatology, Derma 360° Clinic, 011273 Bucharest, Romania Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania Department of Pathophysiology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 020105 Bucharest, Romania Department of Pathology, Colentina Clinical Hospital, 020125 Bucharest, Romania AU - Turcu,Gabriela AU - Nedelcu,Roxana,Ioana AU - Nedelcu,Iulia,Teodora AU - Hodorogea,Anastasia AU - Balaban,Mihaela AU - Brinzea,Alice AU - Nichita,Luciana AU - Popp,Cristiana,Gabriela AU - Zurac,Sabina,Andrada AU - Andrei,Razvan,Theodor DA - 2020/07/01 DO - 10.3892/etm.2019.8150 EP - 41 IS - 1 JO - Exp Ther Med KW - pyoderma gangrenosum hidradenitis suppurativa PY - 2020 SN - 1792-0981 1792-1015 SP - 38 ST - Pyoderma gangrenosum and suppurative hidradenitis association, overlap or spectrum of the same disease? Case report and discussion T2 - Experimental and Therapeutic Medicine TI - Pyoderma gangrenosum and suppurative hidradenitis association, overlap or spectrum of the same disease? Case report and discussion UR - https://doi.org/10.3892/etm.2019.8150 VL - 20 ER -