TY - JOUR AB - Changes of complement and oxidative stress parameters in patients with acute cerebral infarction (ACI) or cerebral hemorrhage (CH), and their clinical significance were explored. A total of 122 patients with ACI or CH admitted to the People's Hospital of Zhangqiu Area from August 2018 to September 2019 were collected. There were 59 ACI patients assigned into a cerebral infarction group (CIG) and further 63 CH patients in a cerebral hemorrhage group (CHG). Additionally, 53 healthy people in physical examination during the same period were enrolled as a control group (CG). Both the CIG and the CHG were treated with edaravone, Xueshuantong, brain protein hydrolysates, aspirin and statin‑related drugs. The levels of complement C3, complement C4, superoxide dismutase (SOD), and total antioxidant capacity (TAC) were determined. Receiver operating characteristic (ROC) curves were employed to analyze the predictive value of C3, C4, SOD and TAG in ACI and CH, and logistic regression was used to analyze the risk factors of stroke. Both CIG and CHG showed higher C3 level, and lower C4, SOD and TAC levels than the CG. The NIHSS <4 group and the NIHSS ≥4 group showed higher hs‑C3 level, and lower SOD and TAC levels than the CG (all P<0.05), and the NIHSS <4 group showed lower C3 level and lower SOD and TAC levels than the NIHSS ≥4 group (all P<0.05). Hypertension and hyperlipidemia were independent risk factors of stroke. The serum complement and oxidative stress parameters in patients with ACI or CH can be determined through routine examination, and the nerve function deficit could be assessed by determining the complement and oxidative stress parameters in clinical practice. AD - Ward Department, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China Rehabilitation Department, Jinan Zhangqiu District Hospital of TCM, Jinan, Shandong 250200, P.R. China Department of Clinical Laboratory, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China Department of Orthopedics, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China Hemodialysis Department, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China Rehabilitation Department, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China AU - Zheng,Mei AU - Wang,Xiaoyan AU - Yang,Jian AU - Ma,Song AU - Wei,Yi AU - Liu,Suping DA - 2020/01/01 DO - 10.3892/etm.2019.8229 EP - 709 IS - 1 JO - Exp Ther Med KW - complement oxidative stress cerebral infarction cerebral hemorrhage PY - 2020 SN - 1792-0981 1792-1015 SP - 703 ST - Changes of complement and oxidative stress parameters in patients with acute cerebral infarction or cerebral hemorrhage and the clinical significance T2 - Experimental and Therapeutic Medicine TI - Changes of complement and oxidative stress parameters in patients with acute cerebral infarction or cerebral hemorrhage and the clinical significance UR - https://doi.org/10.3892/etm.2019.8229 VL - 19 ER -