TY - JOUR AB - Non‑small cell lung cancer (NSCLC) is one of the most common cancer types worldwide. Previous studies have indicated that TOR signaling pathway regulator (TIPRL) is involved in the progression of NSCLC. However, the underlying mechanisms of the role of TIPRL in regulating NSCLC metastasis have remained largely elusive. In the present study, the expression pattern of TIPRL in NSCLC was analyzed using The Cancer Genome Atlas (TCGA) dataset. Furthermore, Kaplan‑Meier curve analysis was performed to evaluate the prognostic value of TIPRL in NSCLC, using the Kaplan‑Meier Plotter and TCGA datasets. Loss‑of‑function assays were performed to determine the effects of TIPRL on cell migration and invasion. The results suggested that TIPRL was upregulated in NSCLC and positively associated with an advanced Tumor‑Node‑Metastasis stage. A higher expression level of TIPRL was associated with shorter overall and disease‑free survival times in patients with NSCLC. To the best of our knowledge, the present study was the first to report that TIPRL acts as a metastasis promoter in NSCLC. Silencing of TIPRL suppressed A549 cell migration and invasion. Mechanistically, the present study indicated that TIPRL knockdown significantly promoted epithelial‑cadherin expression, whereas it suppressed twist and vimentin expression in A549 cells. In conclusion, the present analysis suggested that TIPRL may serve as a biomarker for the prognosis of NSCLC and as a future target for its treatment. AD - Department of Cardiothoracic Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang 315010, P.R. China Shanghai Genechem Translational Medicine Institute, Shanghai 200120, P.R. China AU - Xu,Xiang AU - Zhu,Huangkai AU - Yang,Minglei AU - Zheng,Enkuo AU - Zhou,Yinjie AU - Ni,Junjun AU - Li,Rui AU - Yang,Zhenhua AU - He,Ti AU - Zhao,Guofang DA - 2020/03/01 DO - 10.3892/etm.2019.8358 EP - 1932 IS - 3 JO - Exp Ther Med KW - non‑small cell lung cancer TOR signaling pathway regulator epithelial‑to‑mesenchymal transition migration invasion PY - 2020 SN - 1792-0981 1792-1015 SP - 1925 ST - Knockdown of TOR signaling pathway regulator suppresses cell migration and invasion in non‑small cell lung cancer via the regulation of epithelial‑to‑mesenchymal transition T2 - Experimental and Therapeutic Medicine TI - Knockdown of TOR signaling pathway regulator suppresses cell migration and invasion in non‑small cell lung cancer via the regulation of epithelial‑to‑mesenchymal transition UR - https://doi.org/10.3892/etm.2019.8358 VL - 19 ER -