TY - JOUR AB - Type 2 taste receptor 10 (TAS2R10), belonging to the TAS2R family of bitter receptors, is widely expressed in extra‑oral tissues. However, its biological roles beyond bitterness sensing in the tongue have remained largely elusive. The present study aimed to perform a positive co‑expression analysis using 60,000 Affymetrix expression arrays and 5,000 The Cancer Genome Atlas datasets to uncover such roles. Based on the functional enrichment analysis, it was indicated that in the Gene Ontology (GO) category biological process, TAS2R10 was mostly involved in ‘cellular protein metabolic process’, ‘protein modification process’, ‘cellular protein modification process’ and ‘cellular component assembly’. In the GO category cellular component, the co‑expressed genes were accumulated in ‘Spt‑Ada‑Gcn5 acetyltransferase (SAGA)‑type complex’ and ‘SAGA complex’, and in the category molecular function, they were concentrated in ‘hexosaminidase activity’, ‘cytoskeletal adaptor activity’, ‘cyclin binding’ and ‘β‑N‑acetylhexosaminidase activity’. Of note, it was indicated that TAS2R10 may be involved in ‘ubiquitin‑mediated proteolysis’, which may provide a starting point to fully investigate the detailed functions of TAS2R10 in the future. TAS2R10 was also indicated to be associated with human diseases, i.e. ‘Salmonella infection’. Overall, the present study was the first to perform a comprehensive bioinformatics analysis of the functions of TAS2R10 and provide insight regarding the notion that this gene may have crucial roles beyond bitterness sensing. AD - Department of Endocrinology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai 200135, P.R. China Department of Endocrinology, Punan Hospital of Pudong New District, Shanghai 200125, P.R. China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, P.R. China State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P.R. China AU - Zhu,Hongling AU - Liu,Lianyong AU - Ren,Li AU - Ma,Junhua AU - Hu,Shuanggang AU - Zhu,Zhaohui AU - Zhao,Xuemei AU - Shi,Chao AU - Wang,Xing AU - Zhang,Chaobao AU - Gu,Mingjun AU - Li,Xiangqi DA - 2020/03/01 DO - 10.3892/etm.2019.8397 EP - 1738 IS - 3 JO - Exp Ther Med KW - bitter receptor type 2 taste receptor 10 function disease co‑expression analysis PY - 2020 SN - 1792-0981 1792-1015 SP - 1733 ST - Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis T2 - Experimental and Therapeutic Medicine TI - Systematic prediction of the biological functions of TAS2R10 using positive co‑expression analysis UR - https://doi.org/10.3892/etm.2019.8397 VL - 19 ER -