TY - JOUR AB - Parkinson's disease (PD) is a chronic progressive disease that affects the central nervous system with a variety of symptoms. Although the precise etiology of PD is not yet fully understood, there is evidence to suggest that T cells serve an important role in the pathogenesis of PD. However, how T cells are recruited in the brain tissue remains to be elucidated. The present study utilized human samples from patients with and without PD to investigate the infiltration of T cells in lesions in the central nervous system. A chemically‑induced mouse PD model was also used to investigate the roles of T cells in the pathogenesis of PD. Depletion of CD4+ or CD8+ T cells was achieved using neutralizing antibodies. Adhesion molecule levels were assessed by flow cytometry. The results of the study indicated that T cell infiltration was evident in both human and murine samples of PD. Blocking CD4+ or CD8+ T cells attenuated the severity of murine PD. Intercellular adhesion molecule 1 (ICAM1 or CD54) was upregulated in mouse PD compared with controls, and its receptor, lymphocyte function‑associated antigen‑1 (LFA1) was overexpressed in T cells of the brain in PD mice compared with controls. Furthermore, inhibition of ICAM1 or LFA1 attenuated PD‑associated characteristics in mice. In conclusion, the interaction between ICAM1 and LFA1 plays a role in recruiting T cells to the central nervous system to mediate experimental PD. AD - Department of Geriatrics, Jiangsu Provincial Key Laboratory of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, P.R. China Department of Nephrology, Ningbo Medical Center Lihuili Hospital, Ningbo, Zheijiang 315000, P.R. China Department of Geriatrics, Ningbo First Hospital, Ningbo, Zheijiang 315000, P.R. China AU - Li,Wenjie AU - Chen,Sheng AU - Luo,Yuan AU - Xia,Yezi AU - Ma,Qianqian AU - Yao,Qi AU - Wu,Jianqing DA - 2020/08/01 DO - 10.3892/etm.2020.8758 EP - 1029 IS - 2 JO - Exp Ther Med KW - Parkinson's disease central nervous system inflammation adhesion molecules T cells PY - 2020 SN - 1792-0981 1792-1015 SP - 1021 ST - Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease T2 - Experimental and Therapeutic Medicine TI - Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease UR - https://doi.org/10.3892/etm.2020.8758 VL - 20 ER -