TY - JOUR AB - Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease and hypothyroidism is an organ‑specific autoimmune disease. The two diseases may occur successively or simultaneously. The majority of previous studies observed that thyroid disease was more frequent in patients with SLE than in the general population, particularly those who had a higher incidence of anti‑thyroid antibodies. However, there are no reported cases of SLE with hypothyroidism as the initial clinical manifestation, to the best of our knowledge. The present study reported on a case of SLE with this unusual initial clinical manifestation and reviewed the literature to estimate the prevalence of clinical hypothyroidism in patients with SLE (range, 3.0‑21.4%). The case of the present study had no obvious facial erythema, photosensitivity or recurrent oral ulcers, and only had hypothyroidism as the initial clinical symptom, but the laboratory examination supported the diagnosis of SLE. The present study suggested that in the clinical diagnosis, attention should be paid to screening for connective tissue diseases when diagnosing hypothyroidism, and the importance of thyroid dysfunction should also be recognized in the treatment of SLE. AD - Department of Endocrinology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of VIP Unit, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China AU - Zhang,Xuejiao AU - Xu,Baofeng AU - Liu,Ziwei AU - Gao,Yuanyuan AU - Wang,Qing AU - Liu,Rui DA - 2020/08/01 DO - 10.3892/etm.2020.8788 EP - 1002 IS - 2 JO - Exp Ther Med KW - systemic lupus erythematosus hypothyroidism initial clinical prevalence autoantibodies pericardial effusion PY - 2020 SN - 1792-0981 1792-1015 SP - 996 ST - Systemic lupus erythematosus with hypothyroidism as the initial clinical manifestation: A case report T2 - Experimental and Therapeutic Medicine TI - Systemic lupus erythematosus with hypothyroidism as the initial clinical manifestation: A case report UR - https://doi.org/10.3892/etm.2020.8788 VL - 20 ER -