TY - JOUR AB - The study assessed whether the increased production of interleukin‑1α (IL‑1α) and interleukin‑1β (IL‑1β), as a result of chronic hepatic inflammation, could be the expression of the negative impact on periodontal disease. The study included chronic periodontitis patients who were systemically healthy, chronic periodontitis patients suffering from chronic hepatitis C, as well as control patients, being systemically and periodontally healthy. After periodontal examination and the assessment of certain periodontal parameters, gingival crevicular fluid was collected from all participating patients. By using the enzyme‑linked immunosorbent assay method, a quantitative assessment of IL‑1α and IL‑1β levels was possible. The immunologic results were correlated to the clinical periodontal data. The gingival fluid levels of cytokines were higher for periodontitis patients with chronic hepatitis C than for the systemically healthy periodontitis patients (1.8‑fold higher for IL‑1α and 2.1‑fold higher for IL‑1β). In addition, the gingival fluid cytokine levels were significantly higher for the periodontal patients (with/without chronic hepatitis C) than for the control group. Positive correlations were found between gingival fluid IL‑1α and IL‑1β levels and certain clinical periodontal parameters or the age of the viral hepatitis C diagnosis, in periodontitis patients with chronic hepatitis C. The chronic hepatic inflammation may have an important additional negative impact on the periodontal status, as both inflammatory reactions seem to be promoted by common pro‑inflammatory cytokines. AD - Department of Periodontology, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania Department of Periodontology, Faculty of Dental Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania Department of Periodontology, Faculty of Dental Medicine, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400000 Cluj‑Napoca, Romania Department of Periodontology, Faculty of Dental Medicine, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540139 Targu‑Mures, Romania Department of Periodontology, Faculty of Dental Medicine, ‘Victor Babes’ University of Medicine and Pharmacy, 300230 Timisoara, Romania Department of Biochemistry, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania Department of Immunology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania Department of Gastroenterology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania AU - Surlin,Petra AU - Gheorghe,Dorin ,Nicolae AU - Popescu,Dora ,Maria AU - Martu,Alexandra ,Maria AU - Solomon,Sorina AU - Roman,Alexandra AU - Lazar,Luminita AU - Stratul,Stefan ,Ioan AU - Rusu,Darian AU - Foia,Liliana AU - Boldeanu,Mihail ,Virgil AU - Boldeanu,Lidia AU - Danilescu,Monica AU - Rogoveanu,Ion DA - 2020/09/01 DO - 10.3892/etm.2020.8906 EP - 2386 IS - 3 JO - Exp Ther Med KW - periodontal disease chronic hepatitis C interleukin‑1α interleukin‑1β gingival fluid PY - 2020 SN - 1792-0981 1792-1015 SP - 2381 ST - Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C T2 - Experimental and Therapeutic Medicine TI - Interleukin‑1α and ‑1β assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C UR - https://doi.org/10.3892/etm.2020.8906 VL - 20 ER -