TY - JOUR AB - Postoperative pancreatic fistula (PF) is a major and serious complication that occurs after pancreaticoduodenectomy (PD). The aim of the current study was to evaluate the use of a novel biomarker, presepsin, for predicting clinically relevant postoperative pancreatic fistula (CR‑POPF) after PD. A prospective pilot study was conducted using 30 consecutive patients who underwent PD. Risk factors and candidates for predictive biomarkers for CR‑POPF were statistically analyzed. CR‑POPF (grade B and C; determined according to the guidelines of the International Study Group of Pancreatic Fistula) occurred in 15 patients (50%). Univariate analysis revealed that certain underlying conditions, including non‑pancreatic cancer, smaller pancreatic ducts and soft pancreas texture were significantly associated with CR‑POPF (P=0.005, P=0.004 and P=0.014, respectively). Furthermore, on day 1 post surgery (POD1), white blood cell count (P=0.040), levels of serum amylase (P=0.002) and serum presepsin (P=0.012), and the concentration of presepsin in drainage fluid (P<0.001) were significantly increased in CR‑POPF compared with non‑CR‑POPF cases. Receiver operating characteristic curve analyses revealed that, on POD1, serum amylase and the concentration of presepsin in drainage fluid had an area under the curve value exceeding 0.8. A multivariate logistic regression analysis revealed that a higher concentration of presepsin in the drainage fluid was an independent predictive marker for CR‑POPF (odds ratio, 14.503; 95% confidence interval, 1.750‑120.229; P=0.013). To the best of our knowledge, the present study demonstrated for the first time that presepsin concentration in drainage fluid is a useful marker of CR‑POPF after PD. AD - Department of Surgery, Saga Medical Center Koseikan, Saga 840‑8571, Japan Life Science Research Institution, Saga Medical Center Koseikan, Saga 840‑8571, Japan Clinical Laboratory, Saga Medical Center Koseikan, Saga 840‑8571, Japan Department of Surgery, Saga University Faculty of Medicine, Saga 849‑8501, Japan AU - Hiraki,Masatsugu AU - Miyoshi,Atsushi AU - Sadashima,Eiji AU - Shinkai,Yukio AU - Yasunami,Michio AU - Manabe,Tatsuya AU - Kitahara,Kenji AU - Noshiro,Hirokazu DA - 2020/09/01 DO - 10.3892/etm.2020.8919 EP - 2304 IS - 3 JO - Exp Ther Med KW - presepsin sCD14‑ST soluble CD14 subtype pancreatic fistula pancreaticoduodenectomy PY - 2020 SN - 1792-0981 1792-1015 SP - 2298 ST - The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study T2 - Experimental and Therapeutic Medicine TI - The novel early predictive marker presepsin for postoperative pancreatic fistula: A pilot study UR - https://doi.org/10.3892/etm.2020.8919 VL - 20 ER -