TY - JOUR AB - Cytokines involved in pathogenesis of psoriasis such as interleukins (IL‑1β, IL‑6, IL‑17, IL‑22, IL‑23), interferon‑α, tumor necrosis factor‑α and interferon‑γ can also become therapeutic targets. Research currently uses murine models of imiquimod‑induced psoriatic‑type dermatitis in order to analyze potentially helpful phytotherapeutics for psoriasis treatment: Curcuma longa, Aloe vera, Nigella sativa, Rubia cordifolia, Smilax china, Thespesia populnea, Wrightia tinctoria, Scutellaria baicalensis, Cassia tora, Pongamia pinnata and various Chinese herbal formulas. Psoriasis is a chronic inflammatory disease with complex pathogenic mechanisms that yield abnormal immune responses with clinical and morphological echoes (erythematous, scaly plaques with a histopathological basis made up of alterations i.e. keratinocyte aberrant proliferation, parakeratosis or chronic inflammation). The current therapeutic approach has only been able to manage the disease, without ensuring a certified treatment, thus giving rise to the need for better medications. This novel therapeutic approach has shown promising results in preclinical studies, giving hope for future phytochemical animal‑based studies. AD - Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania Research Center in the Field of Medical and Pharmaceutical Sciences, ‘Dunarea de Jos’ University, 800010 Galati, Romania Department of Neuropsychomotor Rehabilitation, ‘Sf. Ioan’ Emergency Clinical Hospital for Children, 800487 Galati, Romania Clinical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania AU - Niculet,Elena AU - Radaschin,Diana ,Sabina AU - Nastase,Florentina AU - Draganescu,Miruna AU - Baroiu,Liliana AU - Miulescu,Magdalena AU - Arbune,Manuela AU - Tatu,Alin ,Laurentiu DA - 2020/10/01 DO - 10.3892/etm.2020.9013 EP - 3424 IS - 4 JO - Exp Ther Med KW - imiquimod phytotherapeutics interleukins psoriasis curcumin PY - 2020 SN - 1792-0981 1792-1015 SP - 3421 ST - Influence of phytochemicals in induced psoriasis (Review) T2 - Experimental and Therapeutic Medicine TI - Influence of phytochemicals in induced psoriasis (Review) UR - https://doi.org/10.3892/etm.2020.9013 VL - 20 ER -