TY - JOUR AB - Stem cells represent an old niche with various new potential therapeutics. Besides drug treatment, reperfusion procedures and surgical revascularization, stem cell therapy could be a good option in ischemic cardiac diseases. A study was performed on a small group of cases who died of cardiac arrhythmia secondary to scarring myocardial infarctions. Tissue cardiac samples were taken from these cases (from the anterior and lateral wall of the left ventricle), for microscopy examination, in order to investigate the presence of cardiac stem cells (CSC). Multiple series of histological sections were also performed and examined, along with immunohistochemical analysis (IHC). The cells were identified in close contact with the residual ischemic cardiomyocytes, in the proximity of the myocardial collagenous scar, in old myocardial infarctions. They were activated by hypoxic ischemia and were influenced by the capillary microvascular density and the interstitial micro‑environment conditions. In chronic intermittent ischemia they seem to turn themselves from dormant quiescent cells into activated progenitor committed cells. AD - Pathology Department, ‘Sf. Pantelimon’ Emergency Clinical Hospital, 021659 Bucharest, Romania Department of Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania Pediatrics Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania Pathology Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania AU - Ceausu,Zenaida AU - Socea,Bogdan AU - Dimitriu,Mihai ,C.T. AU - Predescu,Dragoş AU - Constantin,Vlad ,D. AU - Bacalbaşa,Nicolae AU - Cîrstoveanu,Cătălin AU - Costache,Mariana AU - Ceausu,Mihai DA - 2020/10/01 DO - 10.3892/etm.2020.9015 EP - 3457 IS - 4 JO - Exp Ther Med KW - cardiac stem cells CD117 CD56 CD34 myocardial infarction PY - 2020 SN - 1792-0981 1792-1015 SP - 3452 ST - Dormant cardiac stem cells: A promising tool in cardiac regeneration T2 - Experimental and Therapeutic Medicine TI - Dormant cardiac stem cells: A promising tool in cardiac regeneration UR - https://doi.org/10.3892/etm.2020.9015 VL - 20 ER -