TY - JOUR AB - Inflammation may play contradictory roles in the pathogenesis of gastroesophageal reflux disease (GERD): gastritis decreases gastric output and reduces the risk of esophagitis, while interleukins may favor mucosal inflammation. The inflammation may cause esogastric motility changes and thus increase the risk of esophagitis. Considering the genetic influence of inflammatory response, we looked for the genetic polymorphisms of IL‑1 in GERD manifested as reflux esophagitis. This is a prospective study carried out in GERD and healthy controls. We assessed in these groups the following single nucleotide polymorphisms (SNPs): IL‑1A (rs1800587), IL‑1B (rs16944), IL‑1B (rs1143634) and the VNTR for IL‑1RN. Both groups were similar according to biographical data. Reflux esophagitis was confirmed by endoscopy and where necessary by pH‑impedance monitoring. Reflux esophagitis was associated only with the polymorphism rs16944. No other correlations with the other three genetic polymorphisms were detected. These data suggest that the diverging effects of proinflammatory factors on the upper digestive tract may have deleterious effect on GERD. The IL‑1B (rs16944) SNP correlates with reflux esophagitis. AD - Faculty of Dental Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400006 Cluj‑Napoca, Romania Department of Molecular Sciences, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania Faculty of Mathematics and Informatics, ‘Babes‑Bolyai’ University, 400084 Cluj‑Napoca, Romania 2nd Department of Internal Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400003 Cluj‑Napoca, Romania AU - Picos,Andrei AU - Vulturar,Romana AU - Picos,Alina AU - Chis,Adina AU - Chiorean,Ioana AU - Piciu,Andra AU - Petrachescu,Narcisa AU - Dumitrascu,Dan,L. DA - 2020/10/01 DO - 10.3892/etm.2020.9030 EP - 3398 IS - 4 JO - Exp Ther Med KW - Gastroesophageal reflux disease genetic polymor­phisms heartburn mucosal inflammation interleukins PY - 2020 SN - 1792-0981 1792-1015 SP - 3394 ST - Interleukin‑1A and interleukin‑1B gene polymorphisms in gastroesophageal reflux disease T2 - Experimental and Therapeutic Medicine TI - Interleukin‑1A and interleukin‑1B gene polymorphisms in gastroesophageal reflux disease UR - https://doi.org/10.3892/etm.2020.9030 VL - 20 ER -