TY - JOUR AB - Antimicrobial peptides (AMPs) are a group of oligopeptides found in most multicellular organisms with a capacity for rapid and nonspecific destruction of pathogens. The action of destroying pathogens is associated with a strong proinflammatory activity, stimulating the secretion of cytokines, chemokines, growth factors but also chemotaxis, the activation of dendritic cells and involving adaptive immunity also. The action of AMPs fits perfectly into the characteristics of innate immunity which makes these peptides candidates to be considered as an important element of this type of immunity. It has been shown that AMPs are involved in a number of cellular processes such as: differentiation, proliferation, maturation, thus widening the degree of involvement of these peptides in the pathogenesis of chronic inflammatory diseases. In psoriasis, AMPs act both as a pro‑inflammatory and chemotaxis factor and through the cathelicidin (LL‑37)/dc DNA complex as a possible autoantigen for T cells, triggering an autoimmune response, activating the Th17/IL23 axis and maintaining the inflammatory process. Thus, many arguments are accumulated to consider that innate immunity through AMPs is an important link in the pathogenesis of psoriasis. Moreover, the action of antimicrobial peptides in psoriasis is almost entirely characteristic for the general mode of action of innate immunity. AD - Department of Dermatovenereology, ‘Dr. Victor Babes’ Clinical Hospital for Infectious and Tropical Diseases, 030303 Bucharest, Romania Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania AU - Alecu,Mihail AU - Coman,Gabriela AU - Mușetescu,Alina AU - Coman,Oana,Andreia DA - 2020/12/01 DO - 10.3892/etm.2020.9322 IS - 6 JO - Exp Ther Med KW - antimicrobial peptides innate immunity psoriasis AMPs defensin psoriasin PY - 2020 SN - 1792-0981 1792-1015 SP - 192 ST - Antimicrobial peptides as an argument for the involvement of innate immunity in psoriasis (Review) T2 - Experimental and Therapeutic Medicine TI - Antimicrobial peptides as an argument for the involvement of innate immunity in psoriasis (Review) UR - https://doi.org/10.3892/etm.2020.9322 VL - 20 ER -