TY - JOUR AB - Hyperlipidemia is a risk factor of kidney damage that can lead to chronic kidney disease. Studies have shown that exercise reduces kidney damage; however, the specific mechanisms underlying the protective effects of exercise remain unclear. For 12 weeks, 8‑week‑old male apolipoprotein E‑deficient (ApoE‑/‑) mice were randomly divided into four treatment groups (n=7/group) as follows: Mice fed a normal diet (ND group); mice fed a ND and exercised (ND + E group); mice fed a high‑fat diet (HD group); and mice fed a HD and exercised (HD + E group). Exercise training consisted of swimming for 40 min, 5 days/week. Metabolic parameters, such as low‑density lipoprotein‑cholesterol, total cholesterol and creatinine levels were higher in the ApoE‑/‑ HD mice compared with those in the ApoE‑/‑ HD + E mice. Serum levels of glutathione peroxidase and superoxide dismutase were significantly decreased in the HD group compared with those in the HD + E group. Significant pathological changes were observed in the HD + E group compared with in the HD group. Immunohistochemistry and immunoblotting revealed increased levels of oxidative stress (nuclear factor erythroid‑2‑related factor 2) and fibrosis (Smad3 and TGF‑β) markers in the ApoE‑/‑ HD group; however, the expression levels of these markers were significantly decreased in the ApoE‑/‑ HD + E group. Furthermore, NF‑κB expression in the HD + E group was significantly lower compared with that in the HD group. These results suggested that exercise may exert protective effects against kidney damage caused by hyperlipidemia. AD - Department of Cardiology, Zhejiang Province Rongjun Hospital, Jiaxing, Zhejiang 314000, P.R. China Department of Internal Medicine, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China Department of Cardiology, Dalian Third People's Hospital Affiliated to Dalian Medical University, Dalian, Liaoning 116200, P.R. China Department of Heart Intensive Care Unit, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China AU - Qian,Chengsi AU - Yang,Qin AU - Guo,Lipeng AU - Zhu,Hupei AU - You,Xi AU - Liu,Hongyang AU - Sun,Yan DA - 2021/02/01 DO - 10.3892/etm.2020.9585 IS - 2 JO - Exp Ther Med KW - hyperlipidemia ApoE‑/‑ mice kidney damage exercise TC PY - 2021 SN - 1792-0981 1792-1015 SP - 153 ST - Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice T2 - Experimental and Therapeutic Medicine TI - Exercise reduces hyperlipidemia‑induced kidney damage in apolipoprotein E‑deficient mice UR - https://doi.org/10.3892/etm.2020.9585 VL - 21 ER -