TY - JOUR AB - Mecasin, a traditional medicine, contains nine herbal constituents: Curcuma longa, Salvia miltio rhiza, Gastrodia elata, Chaenomeles sinensis, Polygala tenuifolia, Paeonia japonica, Glycyrrhiza uralensis, Atractylodes japonica and processed Aconitum carmichaeli. Several biological effects of mecasin have been described both in vivo and in vitro. Previous studies have demonstrated that mecasin has anti‑inflammatory effects. The purpose of the present study was to determine anti‑inflammatory effects of mecasin and its natural product constituents on lipopolysaccharide (LPS)‑stimulated BV2 cells by measuring nitrite and nitric oxide contents. Nitrite production levels in LPS‑stimulated BV2 cells incubated with mecasin and each individual constituent of mecasin were measured. The results suggested that C. longa, P. tenuifolia and P. japonica inhibited nitrite production in a pattern similar to that of mecasin. The effect of mecasin was likely a result of synergistic effects of its natural herb constituents. AD - ALS/MND Center of Wonkwang University Gwangju Korean Medicine Hospital, Gwangju 61729, Republic of Korea Department of Pharmacy, Chosun University, Dong‑gu, Gwangju 61452, Republic of Korea Professional Graduate School, Wonkwang University, Jeonbuk, Iksan 54538, Republic of Korea AU - Wang,Tingting AU - Ko,Wonmin AU - Shin,Joon-Yeong AU - Choi,Dongho AU - Lee,Dong-Sung AU - Kim,Sungchul DA - 2021/06/01 DO - 10.3892/etm.2021.10023 IS - 6 JO - Exp Ther Med KW - mecasin active ingredients BV2 cells anti-inflammatory effect PY - 2021 SN - 1792-0981 1792-1015 SP - 591 ST - Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells T2 - Experimental and Therapeutic Medicine TI - Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells UR - https://doi.org/10.3892/etm.2021.10023 VL - 21 ER -