TY - JOUR
AB - Mecasin, a traditional medicine, contains nine herbal constituents: Curcuma longa, Salvia miltio rhiza, Gastrodia elata, Chaenomeles sinensis, Polygala tenuifolia, Paeonia japonica, Glycyrrhiza uralensis, Atractylodes japonica and processed Aconitum carmichaeli. Several biological effects of mecasin have been described both in vivo and in vitro. Previous studies have demonstrated that mecasin has anti‑inflammatory effects. The purpose of the present study was to determine anti‑inflammatory effects of mecasin and its natural product constituents on lipopolysaccharide (LPS)‑stimulated BV2 cells by measuring nitrite and nitric oxide contents. Nitrite production levels in LPS‑stimulated BV2 cells incubated with mecasin and each individual constituent of mecasin were measured. The results suggested that C. longa, P. tenuifolia and P. japonica inhibited nitrite production in a pattern similar to that of mecasin. The effect of mecasin was likely a result of synergistic effects of its natural herb constituents.
AD - ALS/MND Center of Wonkwang University Gwangju Korean Medicine Hospital, Gwangju 61729, Republic of Korea
Department of Pharmacy, Chosun University, Dong‑gu, Gwangju 61452, Republic of Korea
Professional Graduate School, Wonkwang University, Jeonbuk, Iksan 54538, Republic of Korea
AU - Wang,Tingting
AU - Ko,Wonmin
AU - Shin,Joon-Yeong
AU - Choi,Dongho
AU - Lee,Dong-Sung
AU - Kim,Sungchul
DA - 2021/06/01
DO - 10.3892/etm.2021.10023
IS - 6
JO - Exp Ther Med
KW - mecasin
active ingredients
BV2 cells
anti-inflammatory effect
PY - 2021
SN - 1792-0981
1792-1015
SP - 591
ST - Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells
T2 - Experimental and Therapeutic Medicine
TI - Comparison of anti‑inflammatory effects of Mecasin and its constituents on lipopolysaccharide‑stimulated BV2 cells
UR - https://doi.org/10.3892/etm.2021.10023
VL - 21
ER -