TY - JOUR AB - The current study aimed to compare the outcomes of decompression and interlaminar stabilisation with those of decompression and fusion for the treatment of lumbar degenerative disease (LDD) at a minimum 8‑year follow‑up. The current study also aimed to analyse the risk factors of radiographic adjacent segment degeneration (ASD). A total of 82 consecutive patients with LDD who underwent surgery between June 2007 and February 2011 were retrospectively reviewed. Of these patients, 39 underwent decompression and Coflex interspinous stabilisation (Coflex group) and 43 underwent decompression and posterior lumbar interbody fusion (PLIF) (PLIF group). All patients had a minimum of 8‑years of follow‑up data. Radiographic and clinical outcomes were compared between the groups, and the risk factors of developing radiographic ASD were also evaluated. The Oswestry disability index and visual analogue scale leg and back pain scores of both groups significantly improved compared with the baseline (all P<0.05), and no difference were indicated between the two groups at each follow‑up time point (P>0.05). The Coflex group exhibited preserved mobility (P<0.001), which was associated with a decreased amount of blood loss (P<0.001), shorter duration of surgery (P=0.001), shorter duration of hospital stay and a lower incidence of ASD (12.8 vs. 32.56%; P=0.040) compared with the fusion group. The current study indicated that coflex and fusion technologies are safe and effective for the treatment of LDD, based on long‑term follow‑up data. However, Coflex interspinous stabilisation was revealed to reduce ASD incidence. Under strict indications, Coflex interspinous stabilisation is an effective and safe treatment method. AD - Department of Orthopaedics, Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510030, P.R. China Department of Orthopaedics, The 909th Hospital of People's Liberation Army, The Affiliated Southeast Hospital of Xiamen University, Orthopedic Center of People's Liberation Army, Zhangzhou, Fujian 363000, P.R. China Department of Biomedical Engineering, Hefei University of Technology, Hefei 230009, P.R. China AU - Zheng,Xiaoqing AU - Chen,Zhida AU - Yu,Honglong AU - Zhuang,Jianxiong AU - Yu,Hui AU - Chang,Yunbing DA - 2021/06/01 DO - 10.3892/etm.2021.10027 IS - 6 JO - Exp Ther Med KW - decompression fusion interlaminar stabilisation lumbar degenerative disease adjacent segment degeneration PY - 2021 SN - 1792-0981 1792-1015 SP - 595 ST - A minimum 8-year follow-up comparative study of decompression and coflex stabilization with decompression and fusion T2 - Experimental and Therapeutic Medicine TI - A minimum 8-year follow-up comparative study of decompression and coflex stabilization with decompression and fusion UR - https://doi.org/10.3892/etm.2021.10027 VL - 21 ER -