TY - JOUR AB - Pseudoexfoliation syndrome (PEX) is characterized by the deposition of proteinaceous material in the anterior ocular segment (resulting in ophthalmic pathologies such as glaucoma and increased risk of complications in cataract surgery), but also by several systemic manifestations. The involvement of peri‑ocular tissues in PEX, including the eyelid skin, lacrimal gland, conjunctiva, orbital fat and vessels, as well as the optic nerve, has been reported by several previous studies. The peri‑ocular effects of PEX include the development of eyelid laxity, conjunctival chalasis, tear film abnormalities, pronounced orbital fat atrophy in response to the administration of prostaglandin analogues in pseudoexfoliative glaucoma, deficient orbital vascular supply and biomechanical changes in both the eyeball and the optic nerve. These effects may have important clinical implications, including increased difficulty in cataract surgery, ocular surface disease and eyelid margin malpositions. AD - Department of Ophthalmology, University Hospital of Heraklion, Heraklion 71110, Greece Department of Ophthalmology, Red Cross Hospital, Athens 11526, Greece Department of Anatomy, Medical School, European University of Cyprus, Nicosia 1516, Cyprus Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71003, Greece AU - Detorakis,Efstathios,T. AU - Bontzos,Georgios AU - Drakonaki,Eleni,E. AU - Spandidos,Demetrios,A. DA - 2021/06/01 DO - 10.3892/etm.2021.10082 IS - 6 JO - Exp Ther Med KW - pseudoexfoliation eyelid orbit lacrimal skin PY - 2021 SN - 1792-0981 1792-1015 SP - 650 ST - Changes in peri‑ocular anatomy and physiology in pseudoexfoliation syndrome (Review) T2 - Experimental and Therapeutic Medicine TI - Changes in peri‑ocular anatomy and physiology in pseudoexfoliation syndrome (Review) UR - https://doi.org/10.3892/etm.2021.10082 VL - 21 ER -