TY - JOUR AB - Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum‑effect correlation method was used to identify pharmacologically active substances. The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti‑endotoxin activity of Lonicera japonica. The common chemical constituents of Lonicera japonica were analyzed using LC, and the antipyretic effects and anti‑endotoxin activity were determined using ELISAs. Combining the results of bivariate and principal component analysis methods, eight active constituents were qualitatively and quantitatively analyzed. The results of these analyses indicated that neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and isochlorogenic acids A, B and C served a synergistic role with respect to antipyretic effects and anti‑endotoxin activity. The present study lays a foundation for the future clinical use of Lonicera japonica. AD - School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, P.R. China School of Pharmaceutical Sciences, Guizhou University, Guiyang, Guizhou 550025, P.R. China College of Life Sciences, Guizhou University, Guiyang, Guizhou 550025, P.R. China Guizhou Agricultural Exhibition Hall, Guiyang, Guizhou 550001, P.R. China AU - Ding,Jing-Xin AU - Liu,Chang AU - Liu,Xiong-Wei AU - Yan,Wei-Na AU - Li,Wen-Pei  AU - Shi,Hui AU - Li,Jia-Xin AU - Tang,Cheng-Lin AU - Zhou,Ying DA - 2021/07/01 DO - 10.3892/etm.2021.10097 IS - 1 JO - Exp Ther Med KW - Lonicera japonica antipyretic effect anti‑endotoxin activity spectrum‑effect correlation key substances PY - 2021 SN - 1792-0981 1792-1015 SP - 665 ST - Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of Lonicera japonica using spectrum‑effect correlation T2 - Experimental and Therapeutic Medicine TI - Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of Lonicera japonica using spectrum‑effect correlation UR - https://doi.org/10.3892/etm.2021.10097 VL - 22 ER -