TY - JOUR
AB - Liquid chromatography (LC) is a common and straight forward approach used in the evaluation of the quality of Traditional Chinese Medicines (TCMs). Quality control is a critical step when systematically assessing the efficacy of TCMs. In the present study, the spectrum‑effect correlation method was used to identify pharmacologically active substances. The aim of the present study was to investigate the underlying correlations between common chemical compounds with antipyretic effects and the anti‑endotoxin activity of Lonicera japonica. The common chemical constituents of Lonicera japonica were analyzed using LC, and the antipyretic effects and anti‑endotoxin activity were determined using ELISAs. Combining the results of bivariate and principal component analysis methods, eight active constituents were qualitatively and quantitatively analyzed. The results of these analyses indicated that neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and isochlorogenic acids A, B and C served a synergistic role with respect to antipyretic effects and anti‑endotoxin activity. The present study lays a foundation for the future clinical use of Lonicera japonica.
AD - School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550025, P.R. China
School of Pharmaceutical Sciences, Guizhou University, Guiyang, Guizhou 550025, P.R. China
College of Life Sciences, Guizhou University, Guiyang, Guizhou 550025, P.R. China
Guizhou Agricultural Exhibition Hall, Guiyang, Guizhou 550001, P.R. China
AU - Ding,Jing-Xin
AU - Liu,Chang
AU - Liu,Xiong-Wei
AU - Yan,Wei-Na
AU - Li,Wen-Pei
AU - Shi,Hui
AU - Li,Jia-Xin
AU - Tang,Cheng-Lin
AU - Zhou,Ying
DA - 2021/07/01
DO - 10.3892/etm.2021.10097
IS - 1
JO - Exp Ther Med
KW - Lonicera japonica
antipyretic effect
anti‑endotoxin activity
spectrum‑effect correlation
key substances
PY - 2021
SN - 1792-0981
1792-1015
SP - 665
ST - Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of Lonicera japonica using spectrum‑effect correlation
T2 - Experimental and Therapeutic Medicine
TI - Identification of compounds with antipyretic effects and anti‑endotoxin activity in different species of Lonicera japonica using spectrum‑effect correlation
UR - https://doi.org/10.3892/etm.2021.10097
VL - 22
ER -