TY - JOUR AB - Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide‑based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiological assay using both Gram‑positive and Gram‑negative bacteria were conducted by employing Disk‑Diffusion and 2,3,5‑triphenyltetrazolium chlorine (TTC) methods to assess the antimicrobial effects. Likewise, the antitumor effects on 2D and 3D cell culture systems were assessed using the human colon cancer Caco‑2 cell line and cytotoxic activity was assessed using 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide (MTT) and Alamar blue assays. Results obtained showed that [CH3(CH2)5]4N(Br) possesses an antibacterial potential, particularly in the case of two bacteria, S. aureus (Gram+) and H. influenzae (Gram). Preliminary screening of antiproliferative activity showed moderate activity, except for the concentration of 10 mM. Furthermore, regarding the effect of [CH3(CH2)5]4N(Br) on tumor cell aggregation, positive outcomes were noted. [CH3(CH2)5]4N(Br) presents promising and under‑explored potential to improve antibacterial or anticancer therapies. AD - Faculty of Medicine, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania ANAPATMOL Research Center, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania Faculty of Bioengineering of Animal Resources, ‘Regele Mihai I al României’ Banat University of Agricultural Sciences and Veterinary Medicine, 300645 Timisoara, Romania Faculty of Pharmacy, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania AU - Popescu,Roxana AU - Filimon,Marioara,Nicoleta AU - Vlad,Daliborca,Cristina AU - Verdes,Doina AU - Moatar,Aurica AU - Moise,Georgiana AU - Guran,Kristine AU - Caraba,Ion,Valeriu AU - Ciochina,Liliana,Petculescu AU - Pinzaru,Iulia AU - Dehelean,Cristina,Adriana AU - Dumitrescu,Gabi DA - 2021/07/01 DO - 10.3892/etm.2021.10104 IS - 1 JO - Exp Ther Med KW - antiproliferative antibacterial tetrahexylammonium bromide‑based ionic liquid ionic liquids PY - 2021 SN - 1792-0981 1792-1015 SP - 672 ST - Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids T2 - Experimental and Therapeutic Medicine TI - Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids UR - https://doi.org/10.3892/etm.2021.10104 VL - 22 ER -