TY - JOUR AB - Limonium tetragonum, Triglochin maritimum, Artemisia scoparia and red ginseng have been used as folk remedies for treating a variety of diseases. In the current study, the protective effects of halophyte and red ginseng against ultraviolet (UV)‑induced skin damage were investigated. Halophyte red ginseng complex extract (HRCE) was prepared and its effects on UV‑B irradiated human keratinocytes and mouse skin were studied through ELISA, Western blotting immunofluorescence and histological staining. HRCE inhibited peroxide‑induced damage in human keratinocytes. HRCE also inhibited UVB‑induced collagen and elastin degradation in human keratinocytes and mouse skin. In addition, HRCE inhibited mast cell infiltration in the skin of mice irradiated with UVB light. This effect was likely due to HRCE inhibiting the activation of MAPK and NF‑κB. By protecting the skin from UVB‑induced skin damage, HRCE has the potential to be used in the treatment and prevention of UV‑induced skin damage and photoaging. AD - Department of Food Science and Technology, Jeonbuk National University, Jeonju‑si, Jeollabuk‑do 54896, Republic of Korea Department of Health Management, Jeonju University, Jeonju‑si, Jeollabuk‑do 55069, Republic of Korea Research Institute, Ato Q&A Co., Ltd., Jeonju‑si, Jeollabuk‑do 54840, Republic of Korea Jinandang Farming Association Corporation, Jinan‑gun, Jeollabuk‑do 55442, Republic of Korea AU - Shin,Jae,Young AU - Park,Ji,Hyeon AU - Che,Denis,Nchang AU - Kang,Hyun,Ju AU - Cho,Byoung,Ok AU - Lim,Yi,Teak AU - Jang,Seon,Il DA - 2021/07/01 DO - 10.3892/etm.2021.10114 IS - 1 JO - Exp Ther Med KW - halophyte red ginseng ultraviolet B photoaging PY - 2021 SN - 1792-0981 1792-1015 SP - 682 ST - Protective effects of halophyte complex extract against UVB‑induced damage in human keratinocytes and the skin of hairless mice T2 - Experimental and Therapeutic Medicine TI - Protective effects of halophyte complex extract against UVB‑induced damage in human keratinocytes and the skin of hairless mice UR - https://doi.org/10.3892/etm.2021.10114 VL - 22 ER -