TY - JOUR AB - Hypoxic postconditioning (HPC) has been reported to be a beneficial and promising treatment for global cerebral ischemia (GCI). However, its neuroprotective mechanism remains unclear. The aim of the present study was to determine whether the protective effects of HPC in a rat model of GCI were due to the upregulation of autophagy via the silent information regulator transcript‑1 (SIRT1)/Forkhead box protein 1 (FoxO1) pathway. Morris water maze test revealed that HPC attenuated cognitive damage in GCI rats. HPC also significantly increased the levels of the autophagy‑related protein LC3‑II, SIRT1 and FoxO1 compared with those in the GCI group. However, the HPC‑induced LC3‑II upregulation was blocked by the SIRT1 inhibitor EX527. These results suggested that the beneficial effects of HPC on GCI rats were due to the upregulation of ischemiainduced autophagy and involved the SIRT1/FoxO1 signaling pathway. AD - College of Clinical Medicine, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China College of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China Department of Neurosurgery, The Affiliated Hospital of North China University of Science and Technology, Tangshan, Hebei 063000, P.R. China AU - Liu,Junjie AU - Gong,Zehua AU - Wu,Juan AU - Liu,Shaopeng AU - Wang,Xue AU - Wang,Jingyao AU - Xu,Jiwei AU - Li,Jianmin AU - Zhao,Yaning DA - 2021/07/01 DO - 10.3892/etm.2021.10127 IS - 1 JO - Exp Ther Med KW - hypoxic postconditioning autophagy global cerebral ischemia silent information regulator transcript‑1 Forkhead box protein 1 PY - 2021 SN - 1792-0981 1792-1015 SP - 695 ST - Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral ischemia T2 - Experimental and Therapeutic Medicine TI - Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral ischemia UR - https://doi.org/10.3892/etm.2021.10127 VL - 22 ER -