TY - JOUR
AB - Age‑related macular degeneration (AMD) is the most common cause of visual impairment in developed countries. Inflammation serves a critical role in the pathogenesis of AMD. Gardenia jasminoides is found in several regions of China and is traditionally used as an organic yellow dye but has also been widely used as a therapeutic agent in numerous diseases, including inflammation, depression, hepatic and vascular disorders, which may reflect the variability of functional compounds that are present in Gardenia jasminoides extracts (GJE). To investigate the therapeutic potential of GJE for AMD, ARPE‑19 cells were treated with lipopolysaccharide (LPS) or LPS plus GJE. GJE significantly decreased LPS‑induced expression of proinflammatory cytokines, including IL‑1β, IL‑6 and TNF‑α. In the in vivo study, GJE inhibited CuSO4‑induced migration of primitive macrophages to the lateral line in zebrafish embryos. GJE also attenuated expression of cytokines (IL‑1β, IL‑6 and TNF‑α), NFKB activating protein (nkap) and TLR4 in ARPE‑19 cells. The results of the present study demonstrated the anti‑inflammatory potential of GJE in vitro and in vivo, and suggested GJE as a therapeutic candidate for AMD.
AD - College of Biological and Environmental Engineering, Changsha University, Changsha, Hunan 410022, P.R. China
Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, UK
AU - Chen,Jianrong
AU - Tchivelekete,Gabriel,Mbuta
AU - Zhou,Xinzhi
AU - Tang,Weizhuo
AU - Liu,Fang
AU - Liu,Minzhuo
AU - Zhao,Chenxi
AU - Shu,Xinhua
AU - Zeng,Zhihong
DA - 2021/07/01
DO - 10.3892/etm.2021.10132
IS - 1
JO - Exp Ther Med
KW - age‑related macular degeneration
inflammation
retinal pigment epithelial cells
zebrafish embryos
Gardenia jasminoides
PY - 2021
SN - 1792-0981
1792-1015
SP - 700
ST - Anti‑inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and zebrafish embryos
T2 - Experimental and Therapeutic Medicine
TI - Anti‑inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and zebrafish embryos
UR - https://doi.org/10.3892/etm.2021.10132
VL - 22
ER -