TY - JOUR AB - Chronic obstructive pulmonary disease (COPD) and asthma are chronic respiratory diseases with high prevalence and mortality that significantly alter the quality of life in affected patients. While the cellular and molecular mechanisms engaged in the development and evolution of these two conditions are different, COPD and asthma share a wide array of symptoms and clinical signs that may impede differential diagnosis. However, the distinct signaling pathways regulating cough and airway hyperresponsiveness employ the interaction of different cells, molecules, and receptors. Transient receptor potential cation channel subfamily V member 1 (TRPV1) plays a major role in cough and airway inflammation. Consequently, its agonist, capsaicin, is of substantial interest in exploring the cellular effects and regulatory pathways that mediate these respiratory conditions. Increasingly more studies emphasize the use of capsaicin for the inhalation cough challenge, yet the involvement of TRPV1 in cough, bronchoconstriction, and the initiation of inflammation has not been entirely revealed. This review outlines a comparative perspective on the effects of capsaicin and its receptor in the pathophysiology of COPD and asthma, underlying the complex entanglement of molecular signals that bridge the alteration of cellular function with the multitude of clinical effects. AD - Department of Pneumology IV, ‘Marius Nasta’ Institute of Pneumophtysiology, 050159 Bucharest, Romania Department of Physiology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania Department of Medical Oncology II, ‘Prof. Dr. Alexandru Trestioreanu’ Institute of Oncology, 022328 Bucharest, Romania Department of Oral and Maxillofacial Surgery, ‘Dr. Carol Davila’ Central Military Emergency Hospital, 010825 Bucharest, Romania Department of Dermatology, ‘Dr. Carol Davila’ Central Military Emergency Hospital, 010825 Bucharest, Romania Department of Gastroenterology, Gastroenterology and Internal Medicine Clinic, ‘Dr. Carol Davila’ Central Military Emergency Hospital, 010825 Bucharest, Romania Department of Immunology, ‘Victor Babes’ National Institute of Pathology, 050096 Bucharest, Romania AU - Dumitrache,Mihai-Daniel AU - Jieanu,Ana,Stefania AU - Scheau,Cristian AU - Badarau,Ioana,Anca AU - Popescu,George,Denis Alexandru AU - Caruntu,Ana AU - Costache,Daniel,Octavian AU - Costache,Raluca,Simona AU - Constantin,Carolina AU - Neagu,Monica AU - Caruntu,Constantin DA - 2021/09/01 DO - 10.3892/etm.2021.10349 IS - 3 JO - Exp Ther Med KW - capsaicin chronic obstructive pulmonary disease asthma cough signaling pathways inflammation transient receptor potential cation channel subfamily V member 1 PY - 2021 SN - 1792-0981 1792-1015 SP - 917 ST - Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review) T2 - Experimental and Therapeutic Medicine TI - Comparative effects of capsaicin in chronic obstructive pulmonary disease and asthma (Review) UR - https://doi.org/10.3892/etm.2021.10349 VL - 22 ER -