TY - JOUR AB - Liver X receptors (LXRs) exert anti‑inflammatory effects in animal models of certain respiratory diseases. In the present study, a model of chronic airway remodeling was established in wild‑type and LXR‑deficient mice. Ovalbumin (OVA)‑sensitized mice were chronically administered OVA via inhalation for 8 weeks. Prior to each stimulation, certain wild‑type mice were treated with GW3965, which is a highly selective LXR agonist. The influence of LXRs on airway inflammation, airway hyperresponsiveness and airway remodeling was evaluated. LXRs were indicated to increase airway inflammation and airway hyperresponsiveness, as well as promote airway remodeling. These results suggest that inhibiting LXRs may be a potential method for the treatment of allergic asthma. AD - Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China AU - Zhang,Jinmei AU - Wu,Zhengcan AU - Yu,Fenfang AU - Ye,Liang AU - Gu,Wei AU - Tan,Yan AU - Wang,Li AU - Shi,Ying DA - 2021/09/01 DO - 10.3892/etm.2021.10352 IS - 3 JO - Exp Ther Med KW - liver X receptors asthma airway inflammation airway hyperresponsiveness airway remodeling PY - 2021 SN - 1792-0981 1792-1015 SP - 920 ST - Role of liver‑X‑receptors in airway remodeling in mice with chronic allergic asthma T2 - Experimental and Therapeutic Medicine TI - Role of liver‑X‑receptors in airway remodeling in mice with chronic allergic asthma UR - https://doi.org/10.3892/etm.2021.10352 VL - 22 ER -