TY - JOUR AB - The present study aimed to explore the efficacy of intravenous immunoglobulin (IVIG) injection in neonates with acute lung injury (ALI) and assess its effects on serum inflammatory cytokine levels. The research subjects were 140 neonates with ALI who were evenly distributed into a control group (COG) and a study group (STG). The COG patients were treated routinely, whereas patients in the STG were administered IVIG in addition to the standard treatment received by the COG. The arterial partial pressure of oxygen (PaO2), PaO2/fraction of inspired oxygen (FIO2), mechanical ventilation time and hospitalization time were compared between the two groups. ELISA was used to determine the levels of interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α) in the patients before treatment and at 12, 24 and 36 h after treatment. The Kaplan‑Meier method was used to analyze the survival of the patients, including their survival for 30 days after treatment. The patients were divided into high and low cytokine expression groups based on their mean expression levels of serum IL‑6 and TNF‑α before treatment. After treatment, PaO2 and PaO2/FiO2 were significantly higher and mechanical ventilation and hospitalization time were reduced in the STG in comparison with the COG (all P<0.001). At 12, 24 and 36 h after treatment, serum IL‑6 and TNF‑α levels in the STG were lower than those in the COG (both P<0.05). The 30‑day survival rate after treatment was not significantly different between the two groups (P>0.05). The 30‑day survival rate in the high IL‑6 and high TNF‑α expression COG was lower than that in the low IL‑6 and low TNF‑α expression COG (both P<0.05). The results of the present study indicate that IVIG may improve pulmonary gas exchange, shorten the course of disease and reduce the inflammatory response in neonates with ALI. AD - Neonatal Intensive Care Unit, Women and Children Health Institute of Futian, University of South China, Shenzen, Guangdong 518033, P.R. China Neonatal Intensive Care Unit, Longhua People's Hospital, Shenzhen, Guangdong 518109, P.R. China AU - Wang,Shaohua AU - Tang,Zanmei AU - Zheng,Xuemei AU - Deng,Jian AU - Wang,Zhangxing DA - 2021/09/01 DO - 10.3892/etm.2021.10363 IS - 3 JO - Exp Ther Med KW - immunoglobulin acute lung injury neonate inflammatory cytokine PY - 2021 SN - 1792-0981 1792-1015 SP - 931 ST - Efficacy of human immunoglobulin injection and effects on serum inflammatory cytokines in neonates with acute lung injury T2 - Experimental and Therapeutic Medicine TI - Efficacy of human immunoglobulin injection and effects on serum inflammatory cytokines in neonates with acute lung injury UR - https://doi.org/10.3892/etm.2021.10363 VL - 22 ER -