TY - JOUR AB - Anal fistula is a common and serious complication of Crohn's disease (CD). A sufficiently suitable animal model that may be used to simulate this disease is yet to be established. The aim of the present review was to summarize the different characteristics and experimental methods of commonly used animal models of CD with anal fistula. Electronic databases were searched for studies reporting on the use of this type of animal model. A total of 234 related articles were retrieved, of which six articles met the inclusion criteria; these were used as references for the present review article. The characteristics of the animal models, the advantages and disadvantages of the modeling methods and the similarities with patients with CD and anal fistula were summarized and analyzed. The evidence suggests that a sufficiently suitable animal preclinical model requires to be established. AD - Department of Internal Medicine, School of Medicine, Dalian Medical University, Dalian, Liaoning 116044, P.R. China Gastrointestinal Center, Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China AU - Lu,Shuangshuang AU - Zhu,Keyuan AU - Guo,Yongxin AU - Wang,Enjing AU - Huang,Jin DA - 2021/09/01 DO - 10.3892/etm.2021.10406 IS - 3 JO - Exp Ther Med KW - inflammatory bowel disease Crohn's disease anal fistula animal model PY - 2021 SN - 1792-0981 1792-1015 SP - 974 ST - Evaluation of animal models of Crohn's disease with anal fistula (Review) T2 - Experimental and Therapeutic Medicine TI - Evaluation of animal models of Crohn's disease with anal fistula (Review) UR - https://doi.org/10.3892/etm.2021.10406 VL - 22 ER -