TY - JOUR AB - Dysregulation in the cutaneous wound‑healing process is a consequence of alterations in the efficiency and activity of the various components involved in the healing process. This dysregulation may result in various clinical appearances of a lesion, such as skin ulcers, keloids, hypertrophic and atrophic scars. The collagen type V alpha 2 (COL5A2) gene provides a template for a component of type V collagen, found primarily within the skin basement membrane. Transforming growth factor (TGF)‑β is involved in inflammation, angiogenesis, proliferation of fibroblasts, collagen synthesis and extracellular matrix remodeling. Hypertrophic scar fibroblasts possess a disrupted expression pattern of the TGF‑β signaling compared to normal healing, while an increased TGF‑β signaling reduces the epidermal proli­feration rate, triggering atrophic scarring. In the present study, 71 female patients who had undergone planned Caesarean section, without postoperative complications, were examined. These patients were clinically and molecularly evaluated after developing scars in order to determine the role of TGF‑β1 (rs201700967 and rs200230083) and COL5A2 (rs369072636) in pathological scarring. Clinical scar evaluation was carried out using SCAR and POSAS scales and genotyping was performed by RT‑PCR. No statistical differences were found between the subgroups regarding the genotype and the pathological scarring, since all the patients included were wild‑type allele carriers. Further investigations and a more representative study group may highlight the involvement of COL5A2 and TGF‑β1 single nucleotide variants in pathological scarring. AD - Department of Medical Genetics, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400349 Cluj‑Napoca, Romania First Department of Obstetrics and Gynecology, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400006 Cluj‑Napoca, Romania AU - Ilieș,Roxana,Flavia AU - Aioanei,Casian,Simon AU - Cătană,Andreea AU - Halmagyi,Salomea-Ruth AU - Lukacs,Istvan AU - Tokes,Reka-Eniko AU - Rotar,Ioana,Cristina AU - Pop,Ioan,Victor DA - 2021/10/01 DO - 10.3892/etm.2021.10501 IS - 4 JO - Exp Ther Med KW - COL5A2 TGF‑β1 SNP hypertrophic scar atrophic scar PY - 2021 SN - 1792-0981 1792-1015 SP - 1067 ST - Involvement of COL5A2 and TGF‑β1 in pathological scarring T2 - Experimental and Therapeutic Medicine TI - Involvement of COL5A2 and TGF‑β1 in pathological scarring UR - https://doi.org/10.3892/etm.2021.10501 VL - 22 ER -