TY - JOUR AB - Erythropoietin (EPO) is a 34‑kDa glycoprotein that possesses the potential for angiogenesis, as well as anti‑inflammatory and anti‑apoptotic properties. The present study aimed to examine the effect of EPO on the angiogenesis of dental pulp cells (DPCs) and to explore the underlying mechanisms of these effects. It was demonstrated that EPO not only promoted DPCs proliferation but also induced angiogenesis of DPCs in a paracrine fashion. EPO enhanced the angiogenic capacity by stimulating DPCs to secrete a series of angiogenic cytokines. ELISA confirmed that high concentrations of EPO increased the production of MMP‑3 and angiopoietin‑1 but decreased the secretion of IL‑6. Furthermore, EPO activated the ERK1/2 and p38 signaling pathways in DPCs, while inhibition of these pathways diminished the angiogenesis capacity of DPCs. The present study suggested that EPO may have an important role in the repair and regeneration of dental pulp. AD - Department of Operative Dentistry and Endodontics, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat‑sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, Guangdong 510055, P.R. China Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Department of Stomatology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R. China AU - Gong,Qimei AU - Zeng,Junyu AU - Zhang,Xufang AU - Huang,Yihua AU - Chen,Chanchan AU - Quan,Jingjing AU - Ling,Junqi DA - 2021/10/01 DO - 10.3892/etm.2021.10513 IS - 4 JO - Exp Ther Med KW - erythropoietin dental pulp cells angiogenesis proliferation pulp regeneration PY - 2021 SN - 1792-0981 1792-1015 SP - 1079 ST - Effect of erythropoietin on angiogenic potential of dental pulp cells T2 - Experimental and Therapeutic Medicine TI - Effect of erythropoietin on angiogenic potential of dental pulp cells UR - https://doi.org/10.3892/etm.2021.10513 VL - 22 ER -