TY - JOUR AB - Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases. The present study aimed to investigate the effect of brain‑derived neurotrophic factor (BDNF) on lung function and airway inflammation in a rat model of COPD. A rat model of COPD was established in this study, and anti‑BDNF antibody was injected to observe the effect of BDNF on pulmonary function and airway inflammation. Lung function and hematoxylin and eosin staining analyses were performed. BDNF in the airway was examined using immunohistochemistry, western blotting and enzyme‑linked immunosorbent assay. Levels of oxidant stress and inflammatory cytokines were measured. After long‑term heavy cigarette exposure, pulmonary inflammation and emphysema were observed, while lung function had deteriorated in the COPD, COPD + anti‑BDNF and COPD + normal saline groups. Levels of BDNF expression, malondialdehyde, tumor necrosis factor‑α and interleukin‑6 were increased in rats with COPD compared with control rats, while levels of superoxide dismutase and glutathione peroxidase were decreased. Anti‑BDNF intervention improved airway inflammation. To conclude, anti‑BDNF intervention could alleviate inflammation and improve any imbalance between oxidation and antioxidation in the airway. AD - Medical College, Soochow University, Suzhou, Jiangsu 215031, P.R. China Department of Geriatrics, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu 215300, P.R. China Clinical Research and Lab Center, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu 215300, P.R. China Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, P.R. China AU - Guo,Zhengli AU - Liu,Lei AU - Li,Shasha AU - Xu,Bingqing AU - Xu,Yihui AU - Li,Huiping DA - 2021/10/01 DO - 10.3892/etm.2021.10550 IS - 4 JO - Exp Ther Med KW - chronic obstructive pulmonary disease brain‑derived neurotrophic factor airway oxidant stress PY - 2021 SN - 1792-0981 1792-1015 SP - 1116 ST - Effect of BDNF on airway inflammation in a rat model of COPD T2 - Experimental and Therapeutic Medicine TI - Effect of BDNF on airway inflammation in a rat model of COPD UR - https://doi.org/10.3892/etm.2021.10550 VL - 22 ER -