TY - JOUR AB - The clinical characteristics and risk factors of patients with coronavirus disease 2019 (COVID‑19) with re‑positive or false‑negative test results have so far remained to be determined. The present study provides a cross‑sectional observational study on 134 hospitalized patients selected from Huoshenshan Hospital (Wuhan, China) using cluster sampling. A total of 68 patients had reduced red blood cell (RBC) counts, 55 a decrease in the hemoglobin concentration (HBC) and 73 a decline in hematocrit (HCT). The false‑negative rate of severe acute respiratory syndrome coronavirus‑2 (SARS‑CoV‑2) RNA detection in pharyngeal swab specimens was 18.7%. The absolute lymphocyte count (ALC), RBC, HBC and HCT levels in false‑negative patients were significantly higher than those in patients who tested positive for viral nucleic acids. Multivariate logistic regression analysis indicated that RBC [odds ratio (OR)=0.43, 95% CI: 0.18‑0.99], HBC (OR=0.97, 95% CI: 0.94‑0.99) and ALC (OR=0.43, 95% CI: 0.20‑0.91) were the factors influencing the negative testing results for viral nucleic acid. The rate of re‑positive patients was 16.4%. The white blood cell, RBC, HBC and HCT values in re‑positive patients were lower than those in non‑re‑positive patients. The median (interquartile range) values for RBC, HBC and HCT of male re‑positive patients were 3.95 (3.37, 4.2) x1012/l, 123 (103, 133) g/l and 36.6 (31.1, 39.2)%, respectively, while the RBC, HBC and HCT of female re‑positive patients were 3.54 (3.13, 3.74) x1012/l, 115 (102, 118) g/l and 34.2 (28.5, 34.9)%, respectively. It was determined that RBC, HBC and HCT values had moderate accuracy in predicting SARS‑CoV‑2 recurrence in patients with COVID‑19 using receiver operating curve analysis. The present study suggested that RBC may have an important role in the pathogenesis of COVID‑19. AD - Third Department of Infectious Diseases, Huoshenshan Hospital, Joint Logistics Support Force of The Chinese People's Liberation Army, Wuhan, Hubei 430101, P.R. China Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shanxi 710038, P.R. China Department of Neurosurgery, The Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330008, P.R. China AU - Jiang,Xue AU - Hu,Yan AU - Qu,Xiao-Peng AU - Xu,Dong-Wei AU - Jiang,Hong AU - Li,Chun-Mei AU - Jiang,Hua AU - Wang,Da-Li AU - Li,Gang AU - Zhu,Xin-Gen AU - Liu,Bei DA - 2021/11/01 DO - 10.3892/etm.2021.10685 IS - 5 JO - Exp Ther Med KW - COVID‑19 re‑positive false‑negative erythrocytes PY - 2021 SN - 1792-0981 1792-1015 SP - 1250 ST - Prediction of in‑hospital recurrence and false‑negative results in patients with COVID‑19 by red blood cell values on admission T2 - Experimental and Therapeutic Medicine TI - Prediction of in‑hospital recurrence and false‑negative results in patients with COVID‑19 by red blood cell values on admission UR - https://doi.org/10.3892/etm.2021.10685 VL - 22 ER -