TY - JOUR AB - Peritoneal carcinomatosis, as well as the presence of liver metastases from colorectal cancer, has been long considered as the sign of a systemic disease, transforming the patient into a candidate for palliation and best supportive care. However, in recent decades, progress in the field of medical and surgical oncology has allowed scientists worldwide to produce curative therapeutic strategies for these cases such as hyperthermic intraperitoneal chemotherapy (HIPEC) or extended liver resection. In addition, the association of these two therapies has also been performed with encouraging results. The aim of the current study was to review articles published thus far in regard to the association of these two therapeutic strategies, in order to identify which cases can benefit the most, which is the most efficient agent or combination of agents, and whether these types of therapy should be performed as monotherapy or as a two‑stage procedure. AD - Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania Department of Visceral Surgery, ‘Ponderas’ Academic Hospital, 021188 Bucharest, Romania Department of Cellular, Molecular and Histology Biology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania Department of Anatomy, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540142 Târgu Mureș, Romania Department of Surgery, ‘Sf. Pantelimon’ Emergency Clinical Hospital, 021659 Bucharest, Romania Department of Internal Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania Department of Thoracic Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania Department of Anesthesiology, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania Department of Visceral Surgery, County Emergency Hospital Ilfov, 022104 Bucharest, Romania Department of Cardiovascular Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania AU - Bacalbasa,Nicolae AU - Balescu,Irina AU - Cretoiu,Dragos AU - Halmaciu,Ioana AU - Dimitriu,Mihai AU - Socea,Bogdan AU - Diaconu,Camelia AU - Iliescu,Laura AU - Savu,Cornel AU - Savu,Carmen AU - Filipescu,Alexandru AU - Stoica,Claudia AU - Stiru,Ovidiu DA - 2021/11/01 DO - 10.3892/etm.2021.10702 IS - 5 JO - Exp Ther Med KW - colorectal cancer peritoneal carcinomatosis HIPEC liver metastases therapeutic procedure PY - 2021 SN - 1792-0981 1792-1015 SP - 1267 ST - Determination of whether HIPEC is beneficial in patients with synchronous peritoneal and liver metastases from colorectal cancer (Review) T2 - Experimental and Therapeutic Medicine TI - Determination of whether HIPEC is beneficial in patients with synchronous peritoneal and liver metastases from colorectal cancer (Review) UR - https://doi.org/10.3892/etm.2021.10702 VL - 22 ER -