TY - JOUR AB - Alcoholic liver disease (ALD) is a worldwide health problem with limited therapeutic options, which is associated with gut‑derived endotoxins, particularly lipopolysaccharide (LPS) and intestinal microbiota dysbiosis. Recently, probiotics, synbiotics and other food additive interventions have been shown to be effective in decreasing or preventing the progression of ALD. Bacillus subtilis (B. subtilis) and its metabolic products are widely used as food additives to maintain intestinal health, but the protective effects of B. subtilis against alcohol‑induced liver injury are poorly understood. In the present study a chronic alcohol‑induced liver injury model was constructed based on the Lieber‑DeCarli diet and it aimed to determine whether dietary B. subtilis supplementation may alleviate alcohol‑induced liver injury. Results revealed that prophylactic B. subtilis supplementation partially restored gut microbiota homeostasis and relieved alcohol‑induced intestinal barrier injury, which significantly decreased the translocation of bacterial endotoxins to the blood. In addition, the decreased serum LPS alleviated hepatic inflammation via the toll‑like receptor 4 pathway, resulting in improved hepatic structure and function. These results demonstrated that dietary B. subtilis supplementation imparts novel hepatoprotective functions by improving intestinal permeability and homeostasis. AD - School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261031, P.R. China School of Medicine, Nankai University, Tianjin 300071, P.R. China AU - Zhao,Meiqi AU - Chen,Chuanai AU - Yuan,Zhoujie AU - Li,Wenwen AU - Zhang,Mohan AU - Cui,Nailing AU - Duan,Yitao AU - Zhang,Xiaoqian AU - Zhang,Peng DA - 2021/11/01 DO - 10.3892/etm.2021.10747 IS - 5 JO - Exp Ther Med KW - Bacillus subtilis alcohol‑induced liver injury intestinal integrity and homeostasis gut microbiota PY - 2021 SN - 1792-0981 1792-1015 SP - 1312 ST - Dietary Bacillus subtilis supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice T2 - Experimental and Therapeutic Medicine TI - Dietary Bacillus subtilis supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice UR - https://doi.org/10.3892/etm.2021.10747 VL - 22 ER -