TY - JOUR
AB - Alcoholic liver disease (ALD) is a worldwide health problem with limited therapeutic options, which is associated with gut‑derived endotoxins, particularly lipopolysaccharide (LPS) and intestinal microbiota dysbiosis. Recently, probiotics, synbiotics and other food additive interventions have been shown to be effective in decreasing or preventing the progression of ALD. Bacillus subtilis (B. subtilis) and its metabolic products are widely used as food additives to maintain intestinal health, but the protective effects of B. subtilis against alcohol‑induced liver injury are poorly understood. In the present study a chronic alcohol‑induced liver injury model was constructed based on the Lieber‑DeCarli diet and it aimed to determine whether dietary B. subtilis supplementation may alleviate alcohol‑induced liver injury. Results revealed that prophylactic B. subtilis supplementation partially restored gut microbiota homeostasis and relieved alcohol‑induced intestinal barrier injury, which significantly decreased the translocation of bacterial endotoxins to the blood. In addition, the decreased serum LPS alleviated hepatic inflammation via the toll‑like receptor 4 pathway, resulting in improved hepatic structure and function. These results demonstrated that dietary B. subtilis supplementation imparts novel hepatoprotective functions by improving intestinal permeability and homeostasis.
AD - School of Clinical Medicine, Weifang Medical University, Weifang, Shandong 261031, P.R. China
School of Medicine, Nankai University, Tianjin 300071, P.R. China
AU - Zhao,Meiqi
AU - Chen,Chuanai
AU - Yuan,Zhoujie
AU - Li,Wenwen
AU - Zhang,Mohan
AU - Cui,Nailing
AU - Duan,Yitao
AU - Zhang,Xiaoqian
AU - Zhang,Peng
DA - 2021/11/01
DO - 10.3892/etm.2021.10747
IS - 5
JO - Exp Ther Med
KW - Bacillus subtilis
alcohol‑induced liver injury
intestinal integrity and homeostasis
gut microbiota
PY - 2021
SN - 1792-0981
1792-1015
SP - 1312
ST - Dietary Bacillus subtilis supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice
T2 - Experimental and Therapeutic Medicine
TI - Dietary Bacillus subtilis supplementation alleviates alcohol‑induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice
UR - https://doi.org/10.3892/etm.2021.10747
VL - 22
ER -