TY - JOUR AB - Revision total knee arthroplasty (TKA) is a challenging surgical procedure. Although good results are presented, the outcomes are worse in comparison with those of primary TKA, with a higher failure rate. The main reasons for the failure of revision TKA include: sepsis, loosening and instability. There are multiple variables linked to these results, and it is difficult to determinate the exact cause as it is often a multifactorial issue. These variables may be related to the quality of the index‑procedure (TKA), to the revision procedure or to patient characteristics. The purpose of this review was to highlight the outcomes of revision knee arthroplasty and main factors that may influence the results. Considerable progress has been made during the last 30 years regarding infection treatment and prevention, complex revision prosthetic design and surgical technique development. Although the outcomes have improved over time, patients who undergo revision TKA may need further re‑operations in the future. AD - Department of Orthopedic and Trauma Surgery, ‘Lucian Blaga’ University, 550276 Sibiu, Romania Department of Orthopedic Surgery, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, Romania Department of Orthopedic Surgery, ‘Transilvania’ University, 500036 Brasov, Romania Department of Orthopedic Surgery, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania AU - Roman,Mihai,Dan AU - Russu,Octav AU - Mohor,Calin AU - Necula,Radu AU - Boicean,Adrian AU - Todor,Adrian AU - Mohor,Cosmin AU - Fleaca,Sorin,Radu DA - 2022/01/01 DO - 10.3892/etm.2021.10951 IS - 1 JO - Exp Ther Med KW - total knee arthroplasty revision survival failure outcome analysis PY - 2022 SN - 1792-0981 1792-1015 SP - 29 ST - Outcomes in revision total knee arthroplasty (Review) T2 - Experimental and Therapeutic Medicine TI - Outcomes in revision total knee arthroplasty (Review) UR - https://doi.org/10.3892/etm.2021.10951 VL - 23 ER -