TY - JOUR
AB - Ring finger protein 6 (RNF6), a member of E3 ubiquitin ligases, plays a potential role as a tumour promoter in numerous carcinomas. However, the role and expression of RNF6 in breast cancer (BC) remains to be elucidated. The present study showed that RNF6 upregulation was detected in BC tissues and was associated with short survival in patients with BC. Multivariate analysis also revealed that RNF6 overexpression is an independent predictor for poor outcome of patients with BC. Furthermore, migration and metastasis assay indicated that RNF6 silencing significantly inhibited the invasion and migration of BC cells in vivo and in vitro, and RNF6 suppression decreased YES‑associated protein (YAP) expression. RNF6 promoted the metastatic ability of BC cells via YAP. Mechanistically, RNF6 interacts with mammalian STE20‑like protein kinase 1 (MST1), a key factor that regulates YAP, and promoted its ubiquitination and degradation. Additionally, RNF6 regulated YAP signalling by promoting ubiquitination and degradation of MST1 in BC. Taken together, these data may highlight a role of RNF6 in BC, which could serve as a valuable prognostic indicator and potential therapeutic target for patients with BC.
AD - Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330009, P.R. China
Department of Breast Surgery, The Third Hospital of Nanchang, Nanchang, Jiangxi 330006, P.R. China
AU - Huang,Yajuan
AU - Zou,Yufeng
AU - Jie,Zhigang
DA - 2022/02/01
DO - 10.3892/etm.2021.11041
IS - 2
JO - Exp Ther Med
KW - ring finger protein 6
breast cancer
mammalian STE20‑like protein kinase
migration and invasion
ubiquitination
degradation
PY - 2022
SN - 1792-0981
1792-1015
SP - 118
ST - RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1 Corrigendum in /10.3892/etm.2022.11255
T2 - Experimental and Therapeutic Medicine
TI - RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1 Corrigendum in /10.3892/etm.2022.11255
UR - https://doi.org/10.3892/etm.2021.11041
VL - 23
ER -