TY - JOUR AB - Long considered a skin‑limited condition, psoriasis is currently defined as a chronic, immune‑mediated inflammatory disease, presenting, besides the skin changes, important systemic manifestations, the most common being: psoriatic arthritis, cardiovascular disease, metabolic syndrome, diabetes, inflammatory bowel disease and nonalcoholic steatohepatitis. It is a disease with a strong psycho‑emotional and social impact, both through skin changes such as pruritic, scaly erythematous plaques, and through the association of comorbidities that influence morbidity and mortality. It has been shown that psoriasis is an independent cardiovascular risk factor, with patients developing ischemic heart disease/acute coronary syndrome, hypertension, peripheral arterial disease, or stroke. The chronic inflammatory status of psoriasis and the production of specific cytokines may be the etiopathogenic link to atherosclerosis and cardiovascular disease. Biological therapy may affect atherosclerosis, leading to the arrest of the evolution or even regressing the changes in the atheromatous plaque. The aim of this review was to re‑evaluate the current knowledge regarding the cardiovascular comorbidities associated with psoriasis for optimal management of the patients. AD - Department of Dermatology, Faculty of Medicine ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania Department of Dermatology, ‘Roma’ Medical Center for Diagnosis and Treatment, 011773 Bucharest, Romania Department of Ophthalmology, Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania Department of Dermatology, Railway Clinical Hospital, 700506 Iasi, Romania Department of Oral Dermatology, Faculty of Dental Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania Department of Dermatology, ‘Arcadia’ Hospitals and Medical Centers, 700620 Iasi, Romania Department of Ophthalmology, ‘Sf. Spiridon’ Clinical Emergency County Hospital, 700111 Iasi, Romania Department of Ophthalmology, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania Department of Dermatology, ‘Sf. Spiridon’ Clinical Emergency County Hospital, 700111 Iasi, Romania AU - Branisteanu,Daciana,Elena AU - Nicolescu,Alin,Codrut AU - Branisteanu,Daniel,Constantin AU - Branisteanu,Catalina,Ioana AU - Dragoi,Andreea,Corina AU - Bogdanici,Camelia,Margareta AU - Toader,Mihaela,Paula AU - Tucaliuc,Andreea,Lorena AU - Dimitriu,Andreea AU - Daogaru,Doru AU - Pirvulescu,Ruxandra,Angela AU - Porumb,Elena,Andrese DA - 2022/02/01 DO - 10.3892/etm.2021.11075 IS - 2 JO - Exp Ther Med KW - psoriasis comorbidities cardiovascular disease pathogenesis screening systemic therapy biologic agents PY - 2022 SN - 1792-0981 1792-1015 SP - 152 ST - Cardiovascular comorbidities in psoriasis (Review) T2 - Experimental and Therapeutic Medicine TI - Cardiovascular comorbidities in psoriasis (Review) UR - https://doi.org/10.3892/etm.2021.11075 VL - 23 ER -