TY - JOUR
AB - Psoriasis can be paradoxically associated with human immunodeficiency virus (HIV) infection, having a prevalence similar to the general population but with a more severe evolution. In the genetically predisposed patients with the CW*0602 haplotype, HIV infection can be a triggering factor and a first sign of infection, and lesions can spontaneously remit with immune reconstruction after antiretroviral therapy. Our patient is a 34 year‑old male with recent HIV infection, in spite of being for over 10 years the partner of an HIV‑positive patient with whom the patient has two HIV‑positive children. The patient was diagnosed with psoriasis 7 years ago and was treated topically. The physical examination at HIV diagnosis was overall favorable, with skin findings compatible with disseminated vulgar psoriasis. Following antiretroviral treatment with Triumeq the patient had a favorable viral response, with complete viral suppression after 12 weeks, but the pre‑existent psoriasis lesions worsened. Methotrexate (MTX) treatment followed for 12 weeks, with partial improvement of psoriatic dermatitis. This medication was continued for 1 year, but the lesions reappeared, possibly due to treatment resistance. MTX treatment for psoriasis in the HIV‑infected patient was beneficial, but limited to one year, leaving biologics as possible treatment following therapy under strict monitoring for adverse effects, T‑lymphocyte CD4+ and viral levels.
AD - Department of Clinical Medicine, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galati, Romania
Department of Neurology, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania
Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galați, Romania
AU - Arbune,Manuela
AU - Arbune,Anca-Adriana
AU - Niculet,Elena
AU - Anghel,Lucretia
AU - Fotea,Silvia
AU - Tatu,Alin,Laurentiu
DA - 2022/02/01
DO - 10.3892/etm.2021.11098
IS - 2
JO - Exp Ther Med
KW - psoriasis
HIV
methothrexate
triumeq
biologics
PY - 2022
SN - 1792-0981
1792-1015
SP - 175
ST - Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report
T2 - Experimental and Therapeutic Medicine
TI - Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report
UR - https://doi.org/10.3892/etm.2021.11098
VL - 23
ER -