TY - JOUR AB - Psoriasis can be paradoxically associated with human immunodeficiency virus (HIV) infection, having a prevalence similar to the general population but with a more severe evolution. In the genetically predisposed patients with the CW*0602 haplotype, HIV infection can be a triggering factor and a first sign of infection, and lesions can spontaneously remit with immune reconstruction after antiretroviral therapy. Our patient is a 34 year‑old male with recent HIV infection, in spite of being for over 10 years the partner of an HIV‑positive patient with whom the patient has two HIV‑positive children. The patient was diagnosed with psoriasis 7 years ago and was treated topically. The physical examination at HIV diagnosis was overall favorable, with skin findings compatible with disseminated vulgar psoriasis. Following antiretroviral treatment with Triumeq the patient had a favorable viral response, with complete viral suppression after 12 weeks, but the pre‑existent psoriasis lesions worsened. Methotrexate (MTX) treatment followed for 12 weeks, with partial improvement of psoriatic dermatitis. This medication was continued for 1 year, but the lesions reappeared, possibly due to treatment resistance. MTX treatment for psoriasis in the HIV‑infected patient was beneficial, but limited to one year, leaving biologics as possible treatment following therapy under strict monitoring for adverse effects, T‑lymphocyte CD4+ and viral levels. AD - Department of Clinical Medicine, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galati, Romania Department of Neurology, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galați, Romania AU - Arbune,Manuela AU - Arbune,Anca-Adriana AU - Niculet,Elena AU - Anghel,Lucretia AU - Fotea,Silvia AU - Tatu,Alin,Laurentiu DA - 2022/02/01 DO - 10.3892/etm.2021.11098 IS - 2 JO - Exp Ther Med KW - psoriasis HIV methothrexate triumeq biologics PY - 2022 SN - 1792-0981 1792-1015 SP - 175 ST - Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report T2 - Experimental and Therapeutic Medicine TI - Therapeutic challenges of psoriasis in the HIV‑infected patient: A case report UR - https://doi.org/10.3892/etm.2021.11098 VL - 23 ER -