TY - JOUR AB - Peroral endoscopic myotomy (POEM) is the first‑line treatment of achalasia cardia (AC). However, the efficacy of POEM in treating patients with advanced AC remains to be determined. The aim of the present study was to evaluate the feasibility and clinical outcome of POEM in treating patients with advanced AC involving different esophageal morphologies. The study was a single‑center, retrospective analysis of patients suffering from advanced AC. The primary endpoint was the Eckardt score at the follow‑up examination. Secondary endpoints were procedural‑related details, including the operation time and length of myotomy, adverse events (AEs) and hospital stay, as well as post‑procedural gastroesophageal reflux disease. The technical success rate was 100%. All 50 patients enrolled underwent successful endoscopic myotomy (conventional POEM, n=20; modified POEM, n=30). AEs were observed in 10 patients. During a 6‑ to 50‑month follow‑up period, 41 patients achieved clinical success as evidenced by a decrease in the Eckardt score. Only 3 of 6 patients with a sigmoid‑shaped megaesophagus obtained symptomatic relief. Symptomatic reflux occurred in 13 of 46 patients who completed their follow‑up. In conclusion, POEM is safe, feasible and effective in treating advanced AC. Patients with a sigmoid‑shaped megaesophagus are less likely to report palliation of symptoms. AD - Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China Department of Gastroenterology, The Hospital of Hei Long Jiang Province, Harbin, Heilongjiang 150036, P.R. China Department of Digestive Endoscopy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China AU - Liu,Dan AU - Liu,Yue-Yuan AU - Chen,Jia-Xin AU - Song,Lei AU - Zhou,Yang-Yang AU - Ullah,Saif AU - Zhao,Li-Xia AU - Hai,Bin AU - Zheng,Qing-Fen AU - Li,Dong-Ying AU - He,De-Zhi AU - Liu,Bing-Rong DA - 2021/03/01 DO - 10.3892/etm.2021.9629 IS - 3 JO - Exp Ther Med KW - peroral endoscopic myotomy advanced achalasia cardia esophageal morphology PY - 2021 SN - 1792-0981 1792-1015 SP - 196 ST - Influence of esophageal morphology on the clinical efficacy of peroral endoscopic myotomy in treating advanced achalasia cardia T2 - Experimental and Therapeutic Medicine TI - Influence of esophageal morphology on the clinical efficacy of peroral endoscopic myotomy in treating advanced achalasia cardia UR - https://doi.org/10.3892/etm.2021.9629 VL - 21 ER -