TY - JOUR AB - Numerous studies have explored the suitability of biocompatible materials in regenerative medicine. Platelet concentrates are derived from centrifuged blood and are named according to their biological characteristics, such as platelet-rich plasma, platelet-rich fibrin and concentrated growth factor. Platelet concentrates have gained considerable attention in soft and hard tissue engineering. Indeed, multiple components of autologous platelet concentrates, such as growth factors, fibrin matrix and platelets, serve essential roles in wound healing. Current studies are focused on cutting-edge strategies to meet the requirements for tissue restoration by improving the properties of autologous platelet concentrates. In the present review, applications of platelet concentrates for tissue engineering are discussed, presenting a selection of recent advances and novel protocols. In addition, several aspects of these strategies, such as the advantages of lyophilized platelet concentrates and the combination of platelet concentrates with biomaterials, stem cells or drugs are discussed. The present review aims to summarize novel strategies using platelet concentrates to improve the outcomes of wound healing. AD - Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan 410008, P.R. China Department of Blood Transfusion, Xiangya Hospital, Clinical Transfusion Research Center, Central South University, Changsha, Hunan 410008, P.R. China AU - Ding,Zhen-Yu AU - Tan,Ying AU - Peng,Qian AU - Zuo,Jun AU - Li,Ning DA - 2021/03/01 DO - 10.3892/etm.2021.9657 IS - 3 JO - Exp Ther Med KW - platelet concentrates platelet-rich fibrin wound healing tissue regeneration growth factors PY - 2021 SN - 1792-0981 1792-1015 SP - 226 ST - Novel applications of platelet concentrates in tissue regeneration (Review) T2 - Experimental and Therapeutic Medicine TI - Novel applications of platelet concentrates in tissue regeneration (Review) UR - https://doi.org/10.3892/etm.2021.9657 VL - 21 ER -