TY - JOUR AB - Colchicine has been known and used for over a millennium for its anti‑inflammatory properties, being the treatment of choice for gout and familial Mediterranean fever. A tricyclic alkaloid extracted from the herbaceous plant, Colchicum autumnale, colchicine blocks multiple inflammatory pathways, and has antimitotic and antifibrotic action. Although there are insufficient data on the beneficial mechanism of action, colchicine is a widely used treatment in dermatology, one of the morbid conditions with more evidence of efficacy being recurrent aphthous stomatitis (RAS), a disorder with incompletely known etiopathogenesis and, consequently, with poorly defined treatment. Colchicine is considered as the first therapeutic line in complex or severe aphthoses, significantly relieving pain, decreasing the number of lesions, increasing the free interval between eruptive episodes, without inducing noticeable side effects. We examined the treatment efficacy of colchicine in two cases of chronic, severe RAS, evolving in different morbid contexts, who did not respond to other therapeutic measures. The two cases presented with recurrent aphthous stomatitis with herpetiform aphthae; one patient with Turner syndrome and one patient with major Sutton ulcers. AD - Department of Oral Dermatology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 70015 Iasi, Romania Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 70015 Iasi, Romania Department of Pathophysiology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 70015 Iasi, Romania AU - Toader,Mihaela,Paula AU - Esanu,Irina,Mihaela AU - Taranu,Tatiana AU - Mocanu,Madalina AU - Toader,Stefan DA - 2021/03/01 DO - 10.3892/etm.2021.9712 IS - 3 JO - Exp Ther Med KW - colchicine herpetiform aphthae Sutton ulcers refractory aphthous stomatitis inflammation anti‑inflammatory drugs PY - 2021 SN - 1792-0981 1792-1015 SP - 281 ST - Colchicine in the treatment of refractory aphthous ulcerations: Review of the literature and two case reports T2 - Experimental and Therapeutic Medicine TI - Colchicine in the treatment of refractory aphthous ulcerations: Review of the literature and two case reports UR - https://doi.org/10.3892/etm.2021.9712 VL - 21 ER -