TY - JOUR AB - The present study investigated the expression of endometrial receptivity‑related molecules in patients with polycystic ovary syndrome (PCOS) and different androgen status, insulin resistance (IR) levels, and body mass indexes (BMI) to identify the mechanism underlying their effects on pregnancy outcomes. The present study recruited 43 participants from November 2020 to January 2021, which were classified into five groups: i) Hyperandrogenemia (HA) combined with impaired glucose tolerance group (n=8); ii) HA combined with diabetes mellitus group (n=8); iii) HA combined with non‑IR (NIR) group (n=10); iv) non‑HA (NHA) androgen combined with IR group (n=8); and v) NHA combined with NIR group (n=9). In addition, according to their BMIs, patients were sub‑grouped into lean/normal (n=27), overweight (n=8) or obese (n=8) groups. The mRNA expression levels of endometrial receptivity‑related molecules were detected using reverse transcription‑quantitative PCR. In addition, flow cytometry was used to determine the phenotype and percentage of uterine natural killer cells (uNK). According to the results, patients with PCOS and IR status, HA and obesity (BMI ≥24 kg/m2) demonstrated significantly decreased mRNA expression levels of adiponectin, adiponectin receptor (AdipoR)1, AdipoR2, adapter protein containing PH domain, PTB domain and leucine zipper motif 1, estrogen receptor (ER) α, ERβ, progesterone receptor (PR), IL‑15, integrin β3 avβ3, and insulin‑like growth factor binding protein‑1, but increased mRNA expression levels of IL‑6 and IL‑8 compared with NHA + NIR group or lean/normal group, respectively. In addition, obese patients with PCOS demonstrated increased mRNA expression levels of PR compared with overweight patients. This suggested that insulin resistant status, HA, and obesity could alter the endometrial receptivity of patients with PCOS, which may explain poorer embryo implantation and pregnancy outcomes in clinics. AD - Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China AU - Wang,Can AU - Wen,Yang-Xing AU - Mai,Qing-Yun DA - 2022/03/01 DO - 10.3892/etm.2022.11145 IS - 3 JO - Exp Ther Med KW - polycystic ovary syndrome hyperandrogen status insulin resistance obesity endometrial receptivity PY - 2022 SN - 1792-0981 1792-1015 SP - 221 ST - Impact of metabolic disorders on endometrial receptivity in patients with polycystic ovary syndrome T2 - Experimental and Therapeutic Medicine TI - Impact of metabolic disorders on endometrial receptivity in patients with polycystic ovary syndrome UR - https://doi.org/10.3892/etm.2022.11145 VL - 23 ER -