TY - JOUR AB - Colorectal cancer (CRC) is the third most common cancer type and one of the deadliest cancers worldwide. Transmembrane p24 trafficking protein 3 (TMED3) has previously been indicated to suppress CRC metastasis, but its clinical significance has remained undetermined. In the present study, the expression of TMED3 was indicated to be elevated at the mRNA and protein levels in CRC tumor samples relative to that in para‑cancerous healthy tissue samples (P<0.05). Furthermore, Kaplan‑Meier survival analysis revealed a significant negative association between elevated TMED3 protein levels and overall survival of patients with CRC (P<0.001, log‑rank test). Multivariate Cox regression analysis additionally determined that elevated TMED3 expression in primary CRC tumors was an independent predictor of poor prognosis (P<0.05). These results revealed that elevated TMED3 expression in CRC was associated with patient survival outcomes, suggesting that TMED3 may be a potential prognostic biomarker for this cancer type. AD - Department of Tumor, Anus and Intestine, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China Department of Oncology, Lanxi People's Hospital, Lanxi, Zhejiang 321100, P.R. China AU - Wang,Rong-Fei AU - Hong,Yong-Gang AU - Hao,Li-Qiang AU - Yu,Hai-Tao DA - 2022/04/01 DO - 10.3892/etm.2022.11215 IS - 4 JO - Exp Ther Med KW - transmembrane p24 trafficking protein 3 colorectal cancer biomarker multivariate Cox regression analysis prognosis PY - 2022 SN - 1792-0981 1792-1015 SP - 286 ST - Expression of TMED3 is independently associated with colorectal cancer prognosis T2 - Experimental and Therapeutic Medicine TI - Expression of TMED3 is independently associated with colorectal cancer prognosis UR - https://doi.org/10.3892/etm.2022.11215 VL - 23 ER -