TY - JOUR AB - The physiological process of scarring is a common denominator of interest in a plethora of medical specialties. The molecular basis whereby this process results in pathological scarring for some individuals is poorly understood at present, with clues pointing towards individual predisposition for pathological scarring. Vitamin D and its subsequent pathway plays a key role in skin metabolism and homeostasis, with alterations in the level of vitamin D receptor (VDR) seen within pathological scars. The present study investigated the role of the rs2228570 polymorphism of VDR with regards to scar formation and evolution in a group of 71 female patients recovering from Caesarian section. Blood samples were taken at the time of surgery, and the follow‑up was collected remotely at 3 and 6 months after surgery. The rs2228570 polymorphism was investigated using an RFLP‑PCR protocol. The results demonstrated that the CC genotype, in combination with the Patient Observer Scar Assessment Scale (POSAS) and SCAR scores are associated with pathological scarring, with more studies being necessary to draw a firm conclusion. AD - Department of Medical Genetics, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania 1st Department of Obstetrics and Gynecology, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400006 Cluj‑Napoca, Romania AU - Ilieș,Roxana,Flavia AU - Aioanei,Casian,Simon AU - Halmagyi,Salomea-Ruth AU - Cătană,Andreea AU - Lukacs,Istvan AU - Tokes,Reka-Eniko AU - Rotar,Ioana,Cristina AU - Pop,Ioan,Victor DA - 2022/05/01 DO - 10.3892/etm.2022.11264 IS - 5 JO - Exp Ther Med KW - VDR SNP RFLP‑PCR hypertrophic scar atrophic scar PY - 2022 SN - 1792-0981 1792-1015 SP - 345 ST - Influence of vitamin D receptor polymorphism rs2228570 on pathological scarring T2 - Experimental and Therapeutic Medicine TI - Influence of vitamin D receptor polymorphism rs2228570 on pathological scarring UR - https://doi.org/10.3892/etm.2022.11264 VL - 23 ER -