TY - JOUR AB - Ovarian cancer (OC) is a highly lethal disease among all gynecologic malignant tumor types. Accumulating studies have indicated that certain long non‑coding RNAs (lncRNAs) serve important roles in the development and progression of OC. In a previous study by our group, lncRNA BC041954 was identified as one of the most upregulated lncRNAs in OC. In the present study, the clinical significance of lncRNA BC041954 in OC was evaluated. The expression of BC041954 was detected in OC and non‑tumor tissue (NT) samples using reverse transcription‑quantitative PCR. Furthermore, the association between BC041954 and clinicopathological variables was analyzed using the Chi‑square test. Survival was determined using Kaplan‑Meier analysis. The prognostic significance of BC041954 was evaluated using univariate and multivariate logistic regression analyses. MicroRNA (miRNA)‑lncRNA and miRNA‑mRNA pairs were used to construct the lncRNA‑miRNA‑mRNA competing endogenous RNA network with an in‑house Perl script. BC041954 expression was increased in 103 OC tissues as compared with that in NT tissues. Upregulated BC041954 expression was significantly associated with the International Federation of Gynecology and Obstetrics stage and distant metastasis. Kaplan‑Meier analysis demonstrated that patients with high BC041954 expression had lower overall survival (OS). In the multivariate logistic regression analysis, BC041954 was also identified as an independent poor prognostic factor for OS in patients with OC. The results suggested that overexpression of the lncRNA BC041954 is a poor prognostic indicator in patients with OC. AD - Department of Gynecology and Obstetrics, The Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning 110003, P.R. China AU - Lu,Yan-Ming AU - Guo,Ya-Ru AU - Zhou,Meng-Ya AU - Wang,Yue DA - 2022/06/01 DO - 10.3892/etm.2022.11335 IS - 6 JO - Exp Ther Med KW - ovarian cancer long non‑coding RNA BC041954 prognosis PY - 2022 SN - 1792-0981 1792-1015 SP - 408 ST - Expression and clinical significance of lncRNA BC041954 in ovarian cancer T2 - Experimental and Therapeutic Medicine TI - Expression and clinical significance of lncRNA BC041954 in ovarian cancer UR - https://doi.org/10.3892/etm.2022.11335 VL - 23 ER -