TY - JOUR AB - Cachexia denotes a complex metabolic syndrome featuring severe loss of weight, fatigue and anorexia. In total, 50‑80% of patients suffering from advanced cancer are diagnosed with cancer cachexia, which contributes to 40% of cancer‑­associated mortalities. MicroRNAs (miRNAs) are non‑coding RNAs capable of regulating gene expression. Dysregulated miRNA expression has been observed in muscle tissue, adipose tissue and blood samples from patients with cancer cachexia compared with that of samples from patients with cancer without cachexia or healthy controls. In addition, miRNAs promote and maintain the malignant state of systemic inflammation, while inflammation contributes to cancer cachexia. The present review discusses the role of miRNAs in the progression of cancer cachexia, and assess their diagnostic value and potential therapeutic value. AD - Department of Oncology, Affiliated Hospital of Weifang Medical College, Weifang, Shandong 261000, P.R. China Graduate School, Weifang Medical College, Weifang, Shandong 261000, P.R. China AU - Li,Xin AU - Du,Lidong AU - Liu,Qiang AU - Lu,Zhong DA - 2022/07/01 DO - 10.3892/etm.2022.11373 IS - 1 JO - Exp Ther Med KW - cancer cachexia microRNAs muscular atrophy PY - 2022 SN - 1792-0981 1792-1015 SP - 446 ST - MicroRNAs: Novel players in the diagnosis and treatment of cancer cachexia (Review) T2 - Experimental and Therapeutic Medicine TI - MicroRNAs: Novel players in the diagnosis and treatment of cancer cachexia (Review) UR - https://doi.org/10.3892/etm.2022.11373 VL - 24 ER -