TY - JOUR AB - Dyslipidemia is an umbrella term for a range of lipid metabolic disorders in the body. This condition has been widely reported to greatly increase the risk of cardiovascular diseases, threatening human health. In recent years, advances in molecular biology have deepened understanding of the dyslipidemia‑related signaling pathways and specific mechanisms underlying dyslipidemia. Signaling pathways possess the ability to transmit an extracellular signal to the inside of the cell, leading to specific biological effects. Lipid metabolism disorders and lipid levels in the blood are frequently affected by aberrant alterations in the dyslipidemia‑related signaling pathways. Therefore, further investigations into these pathways are required for the prevention and treatment of dyslipidemia. The present review summarizes the characteristics of six dyslipidemia‑associated signaling pathways: Peroxisome proliferator‑activated receptor, adenosine monophosphate‑activated protein kinase, farnesoid X receptor, forkhead box O, adipocytokine and cyclic adenosine monophosphate signaling pathways. In particular, specific focus was placed on previous experimental studies and reports on the intervention effects of natural substances (compounds from animals, plants, marine organisms and microorganisms) on dyslipidemia. AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Jinghai, Tianjin 301617, P.R. China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Binhai, Tianjin 300301, P.R. China AU - Cao,Ningning AU - Li,Xiaoxuan AU - Zhang,Wanjing AU - Wang,Qingguo AU - Liang,Yujuan AU - Zhou,Fujun AU - Xiao,Xuefeng DA - 2022/08/01 DO - 10.3892/etm.2022.11421 IS - 2 JO - Exp Ther Med KW - dyslipidemia signaling pathway lipid metabolism research progress PY - 2022 SN - 1792-0981 1792-1015 SP - 494 ST - Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) T2 - Experimental and Therapeutic Medicine TI - Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review) UR - https://doi.org/10.3892/etm.2022.11421 VL - 24 ER -