TY - JOUR AB - The 5‑year mortality rates associated with decompensated liver cirrhosis (DLC) can reach 50%, which suggests that this condition poses a serious health risk. In previous studies conducted by our group, autologous bone marrow nucleated cells (ABMNCs) were used to treat HIV‑positive patients with DLC through the right omental vein; however, trauma and poor compliance were encountered. In the present study, the percutaneous liver approach to inject ABMNCs under the guidance of B‑ultrasound was employed for the treatment of DLC. A total of 108 patients with DLC were retrospectively divided into the routine drug treatment group (control group; 30 cases), the right omental vein infusion of ABMNCs group (observation group 1; 38 cases) and the B‑ultrasound‑guided liver injection of ABMNCs group (observation group 2; 40 cases). After treatment, the liver synthesis (prothrombin time, albumin and ascites) and secretion functions (total bilirubin) in observation groups 1 and 2 were significantly improved compared with those of the control group (P<0.01) and the bone marrow function was also significantly improved compared with that of the control group (P<0.01). While, the bone marrow function (white blood cell, platelet, and hemoglobin) in observation group 1 was significantly improved compared with that of observation group 2 at the end of treatment (P<0.01). After a 1‑year follow‑up, the case fatality rate was 2.5% (1/40) in observation group 2, which was significantly lower than the 20% fatality rate (6/30) recorded in the control group (P<0.05). The injection of ABMNCs into the liver under the guidance of B‑ultrasound was significantly better than conventional drug therapy in treating DLC. This approach has obvious advantages such as no hospitalization, minimal trauma, rapid recovery and good compliance, all of which make it worthy of application in primary hospitals. AD - Department of Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, P.R. China Henuo Medical Clinic, Shanghai New Hongqiao International Medical Center, Shanghai 201100, P.R. China Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China Department of Hepatobiliary Surgery, Oriental Hepatobiliary Surgery Hospital Affiliated to Naval Military Medical University, Shanghai 200433, P.R. China AU - Li,Lei AU - Si,Yanhui AU - Cheng,Mingrong AU - Lang,Lin AU - Li,Aijun AU - Liu,Baochi DA - 2022/10/01 DO - 10.3892/etm.2022.11570 IS - 4 JO - Exp Ther Med KW - minimally invasive treatment DLC bone marrow stem cells surgical treatment nucleated cell therapy PY - 2022 SN - 1792-0981 1792-1015 SP - 633 ST - Therapeutic effect of autologous bone marrow cells injected into the liver under the guidance of B‑ultrasound in the treatment of HBV‑related decompensated liver cirrhosis T2 - Experimental and Therapeutic Medicine TI - Therapeutic effect of autologous bone marrow cells injected into the liver under the guidance of B‑ultrasound in the treatment of HBV‑related decompensated liver cirrhosis UR - https://doi.org/10.3892/etm.2022.11570 VL - 24 ER -