TY - JOUR AB - Lipomembranous fat necrosis (LFN) is an uncommon but distinct form of fat necrosis, which is characterized by eosinophilic, crenulated and/or serpiginous membranes. LFN exhibits macrocystic, microcystic and/or crushed features. LFN is routinely detectable on hematoxylin and eosin (H&E)‑stained sections, and is present both in the acute phase and in the later or fibrous stage of necrotic fatty lesions. Smaller crushed LFN embedded within fibrous tissues may be difficult to recognize on H&E‑stained sections, but can be highlighted by some staining techniques, including Masson trichrome, periodic acid‑Schiff, orcein, long Ziehl‑Neelsen stain, silver impregnation, phosphotungstic acid‑hematoxylin and luxol fast blue staining. LFN was initially considered a specific feature of Nasu‑Hakola disease, but has since been identified in various subcutaneous or intraabdominal lesions related to ischemic conditions or venous insufficiency. In addition, LFN is detectable in intra‑articular loose bodies and aortic valves with or without dysfunction, suggesting that LFN is also associated with ischemia‑like hypoxic conditions or malnutrition. LFN is considered to be a histological hallmark of hidden ischemic or hypoxic/malnourished conditions in various diseases; however, the exact mechanisms of LFN remain poorly understood. The present review described the clinicopathological features of this interesting, but poorly characterized, condition. AD - Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan Department of Laboratory Medicine, National Defense Medical College Hospital, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan AU - Matsukuma,Susumu AU - Matsunaga,Ayano AU - Takahashi,Oh AU - Ogata,Sho DA - 2022/12/01 DO - 10.3892/etm.2022.11695 IS - 6 JO - Exp Ther Med KW - aortic valve intraarticular loose body ischemia LFN lipomembranous changes membranocystic changes membranous fat necrosis Nasu‑Hakola disease soft tissue tumor PY - 2022 SN - 1792-0981 1792-1015 SP - 759 ST - Lipomembranous fat necrosis: A distinctive and unique morphology (Review) T2 - Experimental and Therapeutic Medicine TI - Lipomembranous fat necrosis: A distinctive and unique morphology (Review) UR - https://doi.org/10.3892/etm.2022.11695 VL - 24 ER -