TY - JOUR AB - Ferroptosis is a type of non‑apoptotic controlled cell death triggered by oxidative stress and iron‑dependent lipid peroxidation. Ferroptosis is regulated by signalling pathways that are associated with metabolism, including glutathione peroxidase 4 dysfunction, the cystine/glutamate antiporter system, lipid peroxidation and inadequate iron metabolism. Ferroptosis is associated with renal fibrosis; however, further research is required to understand the specific molecular mechanisms involved. The present review aimed to discuss the known molecular mechanisms of ferroptosis and outline the biological reactions that occur during renal fibrosis that may be associated with ferroptosis. Further investigation into the association between ferroptosis and renal fibrosis may lead to the development of novel treatment methods. AD - Department of Nephrology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, P.R. China AU - Zhang,Han,Yin AU - Cheng,Meng AU - Zhang,Lei AU - Wang,Yi,Ping DA - 2023/01/01 DO - 10.3892/etm.2022.11712 IS - 1 JO - Exp Ther Med KW - ferroptosis renal fibrosis molecular mechanisms oxidative stress inflammation autophagy ferritinophagy PY - 2023 SN - 1792-0981 1792-1015 SP - 13 ST - Ferroptosis and renal fibrosis: A new target for the future (Review) T2 - Experimental and Therapeutic Medicine TI - Ferroptosis and renal fibrosis: A new target for the future (Review) UR - https://doi.org/10.3892/etm.2022.11712 VL - 25 ER -