TY - JOUR AB - Intervertebral disc degeneration (IDD) is the leading cause of lower back pain, which is one of the primary factors that lead to disability and pose a serious economic burden. The key pathological processes involved are extracellular matrix degradation, autophagy, apoptosis, and inflammation of nucleus pulposus cells. Non‑coding RNAs (ncRNAs), including microRNAs, long ncRNAs and circular RNAs, are key regulators of the aforementioned processes. ncRNAs are differentially expressed in tissues of the intervertebral disc between healthy individuals and patients and participate in the pathological progression of IDD via a complex pattern of gene regulation. However, the regulatory mechanisms of ncRNAs in IDD remain unclear. The present review summarizes the latest insights into the regulatory role of ncRNAs in IDD and sheds light on potentially novel therapeutic strategies for IDD that may be implemented in the future. AD - Department of Orthopedics, First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China Department of Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China AU - Guo,Cunliang AU - Chen,Yungang AU - Wang,Yuhe AU - Hao,Yanke DA - 2023/01/01 DO - 10.3892/etm.2022.11743 IS - 1 JO - Exp Ther Med KW - 71000331@sdutcm.edu.cn PY - 2023 SN - 1792-0981 1792-1015 SP - 44 ST - Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review) T2 - Experimental and Therapeutic Medicine TI - Regulatory roles of noncoding RNAs in intervertebral disc degeneration as potential therapeutic targets (Review) UR - https://doi.org/10.3892/etm.2022.11743 VL - 25 ER -