TY - JOUR AB - The present randomized controlled study aimed to investigate the effects of TopClosure® tension‑relief system (TRS) on patients with breast cancer undergoing mastectomy. A total of 402 female patients with breast cancer who came to the Renmin Hospital of Wuhan University between March 2014 and June 2018 were involved in the present study. All patients receiving mastectomy were randomly divided into the TRS group (n=201) and the control group (n=201). Serum levels of high‑sensitivity C‑reactive protein, TNF‑α, IL‑6 and procalcitonin were measured using ELISA. Vancouver Scar Scale was recorded at 2 weeks and 1‑3 and 6 months following the operation. The 36‑Item Health Survey Scales were performed for all patients at 1 month after surgery. The TRS reduced the incidence of flap necrosis, infection and the duration of hospital stay. In addition, the TRS was found to attenuate inflammation and improve scar outcomes as well as the quality of life. It was concluded that the TRS could significantly improve the clinical outcomes. AD - Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Cardiovascular Department, Tianyou Hospital Affiliated To Wuhan University of Science and Technology, Wuhan, Hubei 430064, P.R. China AU - Fan,Huajun AU - Jia,Haizhen AU - Zhu,Zhanyong AU - Zhao,Yueqiang AU - Yu,Mosheng DA - 2023/01/01 DO - 10.3892/etm.2022.11769 IS - 1 JO - Exp Ther Med KW - tension‑relief system breast cancer mastectomy clinical outcomes inflammation PY - 2023 SN - 1792-0981 1792-1015 SP - 70 ST - TopClosure® tension‑relief system improves clinical outcomes of patients with breast cancer undergoing mastectomy T2 - Experimental and Therapeutic Medicine TI - TopClosure® tension‑relief system improves clinical outcomes of patients with breast cancer undergoing mastectomy UR - https://doi.org/10.3892/etm.2022.11769 VL - 25 ER -