TY - JOUR
AB - Wet keratin is a hallmark of adamantinomatous craniopharyngioma (ACP), which is frequently infiltrated by inflammatory cells. S100 calcium‑binding protein A9 (S100A9) has been confirmed to play a decisive role in the development of inflammation. However, the relationship between wet keratin (keratin nodules) and S100A9 in ACP is poorly understood. The objective of the present study was to explore the expression of S100A9 in ACP and its association with wet keratin formation. Immunohistochemistry and immunofluorescence were used to detect the expression of S100A9, β‑catenin and Ki67 in 46 cases of ACP. A total of three online databases were used to analyze S100A9 gene expression and protein data. The results revealed that S100A9 was primarily expressed in wet keratin and some intratumoral and peritumoral cells, and its expression in wet keratin was upregulated in the high inflammation group (P=1.800x10‑3). In addition, S100A9 was correlated with the degree of inflammation (r=0.6; P=7.412x10‑3) and the percentage of Ki67‑positive cells (r=0.37; P=1.000x10‑2). In addition, a significant correlation was noted between the area of wet keratin and the degree of inflammation (r=0.51; P=2.500x10‑4). In conclusion, the present study showed that S100A9 was upregulated in ACP and may be closely associated with wet keratin formation and the infiltration of inflammatory cells in ACP.
AD - Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P.R. China
Department of Pathology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China
Department of Neurosurgery, Beijing Luhe Hospital, Capital Medical University, Beijing 101199, P.R. China
AU - Zhao,Chuan
AU - Hu,Wenxin
AU - Luo,Ning
AU - Wang,Xingfu
AU - Lin,Da
AU - Lin,Zhixiong
DA - 2023/06/01
DO - 10.3892/etm.2023.11981
IS - 6
JO - Exp Ther Med
KW - adamantinomatous craniopharyngioma
S100 calcium‑ binding protein A9
Ki67
wet keratin
inflammation
PY - 2023
SN - 1792-0981
1792-1015
SP - 282
ST - Expression of S100A9 in adamantinomatous craniopharyngioma and its association with wet keratin formation
T2 - Experimental and Therapeutic Medicine
TI - Expression of S100A9 in adamantinomatous craniopharyngioma and its association with wet keratin formation
UR - https://doi.org/10.3892/etm.2023.11981
VL - 25
ER -